Investigation of brain hemodynamic changes induced by active and passive movements: A combined arterial spin labeling-bold fMRI study

Ilaria Boscolo Galazzo, Silvia F. Storti, Emanuela Formaggio, Francesca B. Pizzini, Antonio Fiaschi, Alberto Beltramello, Alessandra Bertoldo, Paolo Manganotti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assess the applicability of arterial spin labeling (ASL) in comparison to blood-oxygenationlevel-dependent (BOLD) contrast fMRI in detecting brain activations elicited by active and passive hand movements. Materials and Methods: A block design for ASL and BOLD fMRI was applied in 8 healthy subjects using active and passive hand tasks. Data analyses were performed at individual and group level, comparing both the different movements and the performance of the two techniques. Results: Group analyses showed involvement of the same areas during both tasks, as the contralateral sensorimotor cortex, supplementary motor area, cerebellum, inferior parietal lobes, thalamus. ASL detected smaller activation volumes than BOLD, but the areas had a high degree of colocalization. Few significant differences (P <0.05) were found when the two tasks were compared for the number of activated voxels, coordinates of center of mass, and CBF estimates. Considering together all the areas, the mean %BOLD change was 0.79 ± 0.27 and 0.73 ± 0.24 for the active and passive movements respectively, while the mean %CBF changes were 34.1 ± 8.9 and 27.1 ± 14.8. Conclusion: Our findings confirm passive and active tasks are strongly coupled, supporting the importance of passive tasks as a diagnostic tool in the clinical setting. ASL fMRI proved suitable for functional mapping and quantifying CBF changes, making it a promising technique for patient cohort applications. .

Original languageEnglish
Pages (from-to)937-948
Number of pages12
JournalJournal of Magnetic Resonance Imaging
Volume40
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • ASL
  • BOLD
  • CBF
  • FMRI
  • Passive movement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Fingerprint Dive into the research topics of 'Investigation of brain hemodynamic changes induced by active and passive movements: A combined arterial spin labeling-bold fMRI study'. Together they form a unique fingerprint.

Cite this