Investigation of chronic lymphocytosis in adults

R. Bassan, M. Buzzetti, B. Marini, A. Rambaldi, P. Allavena, T. Barbui

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Thirteen cases of idiopathic chronic lymphocytosis are the subject of this report. Patients showed a lymphocyte count between 4 and 15 x 109/L for at least six months, marrow lymphocytosis not exceeding 25%, absence of lymphomegaly and hepatosplenomegaly, and no associated infectious, immune, or neoplastic disease. Morphologic examination of smears revealed a lymphocytosis of large granular lymphocytes in five. A selected battery of polyclonal and monoclonal antisera to antigens commonly found on B-, T-, and natural killer cells allowed the identification of six cases of early B-cell chronic lymphocytic leukemia, two cases of T-cell lymphocytosis with a suppressor or helper T-cell phenotype, and five cases of large granular lymphocyte/natural killer cell proliferative disease. The results demonstrate the usefulness of combining morphologic and phenotype studies for the investigation of chronic lymphocytosis, which often appears as an early leukemia or a benign clonal proliferative disorder of lymphocyte subsets.

Original languageEnglish
Pages (from-to)783-787
Number of pages5
JournalAmerican Journal of Clinical Pathology
Issue number6
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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