Investigation of dietary factors and endometrial cancer risk using a nutrient-wide association study approach in the EPIC and nurses' health study (NHS) and NHSII

Melissa A. Merritt, Ioanna Tzoulaki, Shelley S. Tworoger, Immaculata De Vivo, Susan E. Hankinson, Judy Fernandes, Konstantinos K. Tsilidis, Elisabete Weiderpass, Anne Tjønneland, Kristina E N Petersen, Christina C. Dahm, Kim Overvad, Laure Dossus, Marie Christine Boutron-Ruault, Guy Fagherazzi, Renée T. Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Heiner Boeing, Antonia TrichopoulouChristina Bamia, Dimitrios Trichopoulos, Domenico Palli, Sara Grioni, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, H. B. Bueno-De-Mesquita, N. Charlotte Onland-Moret, Petra H. Peeters, Inger T. Gram, Guri Skeie, J. Ramón Quirós, Eric J. Duell, María José Sánchez, D. Salmerón, Aurelio Barricarte, Saioa Chamosa, Ulrica Ericson, Emily Sonestedt, Lena Maria Nilsson, Annika Idahl, Kay Tee Khaw, Nicholas Wareham, Ruth C. Travis, Sabina Rinaldi, Isabelle Romieu, Chirag J. Patel, Elio Riboli, Marc J. Gunter

Research output: Contribution to journalArticle

Abstract

Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cancer risk associations for dietary intake of 84 foods and nutrients based on dietary questionnaires in three prospective studies, the European Prospective Investigation into Cancer and Nutrition (EPIC; N = 1,303 cases) followed by validation of nine foods/nutrients (FDR ≤ 0.10) in the Nurses' Health Studies (NHS/NHSII; N = 1,531 cases). Cox regression models were used to estimate HRs and 95% confidence intervals (CI). In multivariate adjusted comparisons of the extreme categories of intake at baseline, coffee was inversely associated with endometrial cancer risk (EPIC, median intake 750 g/day vs. 8.6; HR, 0.81; 95% CI, 0.68-0.97, Ptrend = 0.09; NHS/NHSII, median intake 1067 g/day vs. none; HR, 0.82; 95% CI, 0.70-0.96, Ptrend = 0.04). Eight other dietary factors that were associated with endometrial cancer risk in the EPIC study (total fat, monounsaturated fat, carbohydrates, phosphorus, butter, yogurt, cheese, and potatoes) were not confirmed in the NHS/NHSII. Our findings suggest that coffee intake may be inversely associated with endometrial cancer risk. Further data are needed to confirm these findings and to examine the mechanisms linking coffee intake to endometrial cancer risk to develop improved prevention strategies.

Original languageEnglish
Pages (from-to)466-471
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

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Endometrial Neoplasms
Nurses
Food
Health
Coffee
Confidence Intervals
Fats
Yogurt
Butter
Cheese
Solanum tuberosum
Proportional Hazards Models
Phosphorus
Eating
Carbohydrates
Prospective Studies
Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Investigation of dietary factors and endometrial cancer risk using a nutrient-wide association study approach in the EPIC and nurses' health study (NHS) and NHSII. / Merritt, Melissa A.; Tzoulaki, Ioanna; Tworoger, Shelley S.; De Vivo, Immaculata; Hankinson, Susan E.; Fernandes, Judy; Tsilidis, Konstantinos K.; Weiderpass, Elisabete; Tjønneland, Anne; Petersen, Kristina E N; Dahm, Christina C.; Overvad, Kim; Dossus, Laure; Boutron-Ruault, Marie Christine; Fagherazzi, Guy; Fortner, Renée T.; Kaaks, Rudolf; Aleksandrova, Krasimira; Boeing, Heiner; Trichopoulou, Antonia; Bamia, Christina; Trichopoulos, Dimitrios; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Sacerdote, Carlotta; Mattiello, Amalia; Bueno-De-Mesquita, H. B.; Onland-Moret, N. Charlotte; Peeters, Petra H.; Gram, Inger T.; Skeie, Guri; Quirós, J. Ramón; Duell, Eric J.; Sánchez, María José; Salmerón, D.; Barricarte, Aurelio; Chamosa, Saioa; Ericson, Ulrica; Sonestedt, Emily; Nilsson, Lena Maria; Idahl, Annika; Khaw, Kay Tee; Wareham, Nicholas; Travis, Ruth C.; Rinaldi, Sabina; Romieu, Isabelle; Patel, Chirag J.; Riboli, Elio; Gunter, Marc J.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 24, No. 2, 01.02.2015, p. 466-471.

Research output: Contribution to journalArticle

Merritt, MA, Tzoulaki, I, Tworoger, SS, De Vivo, I, Hankinson, SE, Fernandes, J, Tsilidis, KK, Weiderpass, E, Tjønneland, A, Petersen, KEN, Dahm, CC, Overvad, K, Dossus, L, Boutron-Ruault, MC, Fagherazzi, G, Fortner, RT, Kaaks, R, Aleksandrova, K, Boeing, H, Trichopoulou, A, Bamia, C, Trichopoulos, D, Palli, D, Grioni, S, Tumino, R, Sacerdote, C, Mattiello, A, Bueno-De-Mesquita, HB, Onland-Moret, NC, Peeters, PH, Gram, IT, Skeie, G, Quirós, JR, Duell, EJ, Sánchez, MJ, Salmerón, D, Barricarte, A, Chamosa, S, Ericson, U, Sonestedt, E, Nilsson, LM, Idahl, A, Khaw, KT, Wareham, N, Travis, RC, Rinaldi, S, Romieu, I, Patel, CJ, Riboli, E & Gunter, MJ 2015, 'Investigation of dietary factors and endometrial cancer risk using a nutrient-wide association study approach in the EPIC and nurses' health study (NHS) and NHSII', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 2, pp. 466-471. https://doi.org/10.1158/1055-9965.EPI-14-0970
Merritt, Melissa A. ; Tzoulaki, Ioanna ; Tworoger, Shelley S. ; De Vivo, Immaculata ; Hankinson, Susan E. ; Fernandes, Judy ; Tsilidis, Konstantinos K. ; Weiderpass, Elisabete ; Tjønneland, Anne ; Petersen, Kristina E N ; Dahm, Christina C. ; Overvad, Kim ; Dossus, Laure ; Boutron-Ruault, Marie Christine ; Fagherazzi, Guy ; Fortner, Renée T. ; Kaaks, Rudolf ; Aleksandrova, Krasimira ; Boeing, Heiner ; Trichopoulou, Antonia ; Bamia, Christina ; Trichopoulos, Dimitrios ; Palli, Domenico ; Grioni, Sara ; Tumino, Rosario ; Sacerdote, Carlotta ; Mattiello, Amalia ; Bueno-De-Mesquita, H. B. ; Onland-Moret, N. Charlotte ; Peeters, Petra H. ; Gram, Inger T. ; Skeie, Guri ; Quirós, J. Ramón ; Duell, Eric J. ; Sánchez, María José ; Salmerón, D. ; Barricarte, Aurelio ; Chamosa, Saioa ; Ericson, Ulrica ; Sonestedt, Emily ; Nilsson, Lena Maria ; Idahl, Annika ; Khaw, Kay Tee ; Wareham, Nicholas ; Travis, Ruth C. ; Rinaldi, Sabina ; Romieu, Isabelle ; Patel, Chirag J. ; Riboli, Elio ; Gunter, Marc J. / Investigation of dietary factors and endometrial cancer risk using a nutrient-wide association study approach in the EPIC and nurses' health study (NHS) and NHSII. In: Cancer Epidemiology Biomarkers and Prevention. 2015 ; Vol. 24, No. 2. pp. 466-471.
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T1 - Investigation of dietary factors and endometrial cancer risk using a nutrient-wide association study approach in the EPIC and nurses' health study (NHS) and NHSII

AU - Merritt, Melissa A.

AU - Tzoulaki, Ioanna

AU - Tworoger, Shelley S.

AU - De Vivo, Immaculata

AU - Hankinson, Susan E.

AU - Fernandes, Judy

AU - Tsilidis, Konstantinos K.

AU - Weiderpass, Elisabete

AU - Tjønneland, Anne

AU - Petersen, Kristina E N

AU - Dahm, Christina C.

AU - Overvad, Kim

AU - Dossus, Laure

AU - Boutron-Ruault, Marie Christine

AU - Fagherazzi, Guy

AU - Fortner, Renée T.

AU - Kaaks, Rudolf

AU - Aleksandrova, Krasimira

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Grioni, Sara

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Mattiello, Amalia

AU - Bueno-De-Mesquita, H. B.

AU - Onland-Moret, N. Charlotte

AU - Peeters, Petra H.

AU - Gram, Inger T.

AU - Skeie, Guri

AU - Quirós, J. Ramón

AU - Duell, Eric J.

AU - Sánchez, María José

AU - Salmerón, D.

AU - Barricarte, Aurelio

AU - Chamosa, Saioa

AU - Ericson, Ulrica

AU - Sonestedt, Emily

AU - Nilsson, Lena Maria

AU - Idahl, Annika

AU - Khaw, Kay Tee

AU - Wareham, Nicholas

AU - Travis, Ruth C.

AU - Rinaldi, Sabina

AU - Romieu, Isabelle

AU - Patel, Chirag J.

AU - Riboli, Elio

AU - Gunter, Marc J.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cancer risk associations for dietary intake of 84 foods and nutrients based on dietary questionnaires in three prospective studies, the European Prospective Investigation into Cancer and Nutrition (EPIC; N = 1,303 cases) followed by validation of nine foods/nutrients (FDR ≤ 0.10) in the Nurses' Health Studies (NHS/NHSII; N = 1,531 cases). Cox regression models were used to estimate HRs and 95% confidence intervals (CI). In multivariate adjusted comparisons of the extreme categories of intake at baseline, coffee was inversely associated with endometrial cancer risk (EPIC, median intake 750 g/day vs. 8.6; HR, 0.81; 95% CI, 0.68-0.97, Ptrend = 0.09; NHS/NHSII, median intake 1067 g/day vs. none; HR, 0.82; 95% CI, 0.70-0.96, Ptrend = 0.04). Eight other dietary factors that were associated with endometrial cancer risk in the EPIC study (total fat, monounsaturated fat, carbohydrates, phosphorus, butter, yogurt, cheese, and potatoes) were not confirmed in the NHS/NHSII. Our findings suggest that coffee intake may be inversely associated with endometrial cancer risk. Further data are needed to confirm these findings and to examine the mechanisms linking coffee intake to endometrial cancer risk to develop improved prevention strategies.

AB - Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cancer risk associations for dietary intake of 84 foods and nutrients based on dietary questionnaires in three prospective studies, the European Prospective Investigation into Cancer and Nutrition (EPIC; N = 1,303 cases) followed by validation of nine foods/nutrients (FDR ≤ 0.10) in the Nurses' Health Studies (NHS/NHSII; N = 1,531 cases). Cox regression models were used to estimate HRs and 95% confidence intervals (CI). In multivariate adjusted comparisons of the extreme categories of intake at baseline, coffee was inversely associated with endometrial cancer risk (EPIC, median intake 750 g/day vs. 8.6; HR, 0.81; 95% CI, 0.68-0.97, Ptrend = 0.09; NHS/NHSII, median intake 1067 g/day vs. none; HR, 0.82; 95% CI, 0.70-0.96, Ptrend = 0.04). Eight other dietary factors that were associated with endometrial cancer risk in the EPIC study (total fat, monounsaturated fat, carbohydrates, phosphorus, butter, yogurt, cheese, and potatoes) were not confirmed in the NHS/NHSII. Our findings suggest that coffee intake may be inversely associated with endometrial cancer risk. Further data are needed to confirm these findings and to examine the mechanisms linking coffee intake to endometrial cancer risk to develop improved prevention strategies.

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