Investigation of radiation-induced multilayered signalling response of the inflammatory pathway

G. Babini, M. Ugolini, J. Morini, G. Baiocco, L. Mariotti, P. Tabarelli de Fatis, M. Liotta, A. Ottolenghi

Research output: Contribution to journalArticle

Abstract

Ionising radiation exposure of cells might induce the perturbation of cell functions and, in particular, the activation or inhibition of several important pathways. This perturbation can cause the deregulation of both intra- and extra-cellular signalling cascades (such as the inflammatory pathway) and alter not only the behaviour of directly exposed cells but also the neighbouring non-irradiated ones, through the so-called bystander effect. The aim of the present work was to investigate the complex nonlinear interactions between the inflammatory pathway and other strictly interlaced signalling pathways, such as Erk1/2 and Akt/PKB, focusing on the radiation-induced perturbation of such pathways in the dose range of 0-2 Gy. The results show how radiation affects these interconnected pathways and how confounding factors, such as the change of culture medium, can hide radiation-induced perturbations.

Original languageEnglish
Article numberncv132
Pages (from-to)157-160
Number of pages4
JournalRadiation Protection Dosimetry
Volume166
Issue number1-4
DOIs
Publication statusPublished - Sep 1 2015

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation
  • Public Health, Environmental and Occupational Health

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