Investigation of reflexes from volume and baroreceptors during converting-enzyme inhibition in humans

Cristina Giannattasio, Guido Grassi, Gino Seravalle, Alberto Morganti, Alberto Zanchetti, Giuseppe Mancia

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

This article emphasizes the importance of testing baroreceptor and cardiopulmonary receptor control of circulation during angiotensin-converting enzyme (ACE) inhibitor treatment in hypertensives, because removal of angiotensin II-dependent stimulation of the sympathetic nervous system could impair reflex blood pressure homeostasis. In essential hypertensive subjects, the sympathetic vasoconstriction that occurs in skeletal muscle after deactivation of cardiopulmonary receptors was reduced after short-term or prolonged administration of the ACE inhibitor, captopril. However, another sympathetic target of the cardiopulmonary reflex, that is, renin release, was unaltered by both short-term and prolonged administration of captopril. Furthermore, the blood pressure and heart rate influences of arterial baroreceptors were preserved or even enhanced after administration of captopril. Thus important reflex mechanisms for cardiovascular homeostasis are not adversely affected by ACE inhibition, which preserves blood pressure levels during gravity challenges or exercise. Preliminary data suggest that this may be even more evident for benazepril.

Original languageEnglish
Pages (from-to)740-745
Number of pages6
JournalAmerican Heart Journal
Volume117
Issue number3
DOIs
Publication statusPublished - 1989

Fingerprint

Baroreflex
Captopril
Reflex
Pressoreceptors
Blood Pressure
Angiotensin-Converting Enzyme Inhibitors
Homeostasis
Enzymes
Sympathetic Nervous System
Gravitation
Peptidyl-Dipeptidase A
Vasoconstriction
Renin
Angiotensin II
Skeletal Muscle
Heart Rate
Inhibition (Psychology)
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Investigation of reflexes from volume and baroreceptors during converting-enzyme inhibition in humans. / Giannattasio, Cristina; Grassi, Guido; Seravalle, Gino; Morganti, Alberto; Zanchetti, Alberto; Mancia, Giuseppe.

In: American Heart Journal, Vol. 117, No. 3, 1989, p. 740-745.

Research output: Contribution to journalArticle

Giannattasio, Cristina ; Grassi, Guido ; Seravalle, Gino ; Morganti, Alberto ; Zanchetti, Alberto ; Mancia, Giuseppe. / Investigation of reflexes from volume and baroreceptors during converting-enzyme inhibition in humans. In: American Heart Journal. 1989 ; Vol. 117, No. 3. pp. 740-745.
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