Investigation of the autonomic nervous system control of cardiovascular variables using fMRI and carotid stimulation

Giovanni Calcagnini, Eugenio Mattei, Michele Triventi, Barbara Basile, Andrea Bassi, Marco Bozzali, Stefano Strano, Pietro Bartolini

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Noninvasive neuroimaging using fMRI has the potential to identify the brain regions involved in the processing of autonomic signals. An event-related design was employed to randomly administer 50 efficacious (-60 mmHg) and 30 non-efficacious (-10 mmHg) neck-suction stimuli, with a duration of 8 s each. Six-hundred echo-planar imaging volumes (TR=2.08 ms) with BOLD contrast, covering the whole brain, were collected in each experiment (total duration 20 min). A stimulus-response curve was obtained by averaging the uniformly resampled RR intervals following each stimulation. Fifteen informed volunteers underwent fMRI at 3T during neck suction stimulation. Nine subjects responded to the stimulation, whereas in six subjects the heart period did not show a significant increase during the suction. Efficacious versus nonefficacious stimuli induced a significantly cluster-level increased activation (p

Original languageEnglish
Title of host publicationComputing in Cardiology
Number of pages4
Publication statusPublished - 2010
EventComputing in Cardiology 2010, CinC 2010 - Belfast, United Kingdom
Duration: Sep 26 2010Sep 29 2010


OtherComputing in Cardiology 2010, CinC 2010
Country/TerritoryUnited Kingdom

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine


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