Investigation on the humoral immune response in patients with gastro-intestinal cancer.

L. Quintiliani, P. Iudicone, M. Di Girolamo, A. Buzzonetti, E. Giuliani, M. Guglielmetti, R. Scocchera, L. Severi, F. Martini, I. Van Axel

Research output: Contribution to journalArticle

Abstract

The humoral immune reactivity was studied in patients affected by gastro-intestinal cancer. The number of peripheral B lymphocytes, the concentration of serum immunoglobulins (Ig) and of C3 complement factor and the frequency of circulating immuno complexes (CIC) did not significantly differ between patients and age-matched controls, while the C4 factor level was significantly increased. The frequency of serum monoclonal components (M-components) was higher in the patients than in the elderly subjects. Moreover the results concerning the "in vitro" functional response of patient B lymphocytes showed a significant decrease of the proliferative responses to Staphylococcus Aureus Cowan I (SAC) and a significant increase of the IgG and IgM synthesis by peripheral blood mononuclear cells (PBMC) in unstimulated and pokeweed mitogen (PWM) stimulated cultures. The meaning of these results, taken together with those reported by others, is discussed.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume69
Issue number2
Publication statusPublished - Jun 1990

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Investigation on the humoral immune response in patients with gastro-intestinal cancer.'. Together they form a unique fingerprint.

  • Cite this

    Quintiliani, L., Iudicone, P., Di Girolamo, M., Buzzonetti, A., Giuliani, E., Guglielmetti, M., Scocchera, R., Severi, L., Martini, F., & Van Axel, I. (1990). Investigation on the humoral immune response in patients with gastro-intestinal cancer. Bollettino dell'Istituto Sieroterapico Milanese, 69(2), 397-404.