Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose To evaluate the impact of fluid-attenuated-inversion-recovery MRI (FLAIR/MRI) and Carbon-11-labeled-methionine PET (11C-MET-PET) on high grade glioma (HGG) tumor volume delineation for radiotherapy planning. Material and methods Sixty-nine patients with HGG were evaluated. The clinical target volumes (CTV1, generated by adding a 10 mm margin to FLAIRMRI area, CTV2 by adding a 20 mm margin to enhanced T1MRI) and biological target volume (BTV) were delineated on pre-operative MRI images and 11CMETPET respectively. Results The overlap between CTV1 and CTV2 showed a low correlation between the two volumes with CTV1 not always fully included into the CTV2. In all cases the whole BTV was included into the CTV1, while in 35/69 patients (50%) part of BTV was outside the CTV2 despite larger margins were added. In all cases recurrences were within the CTV1 volume and in 19/38 (50%) partially outside the CTV2. In all patients relapse corresponded to the BTV area. Conclusions Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalRadiotherapy and Oncology
Volume112
Issue number3
DOIs
Publication statusPublished - Sep 1 2014

Keywords

  • High grade glioma
  • MET-PET
  • Radiotherapy-planning

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma'. Together they form a unique fingerprint.

Cite this