Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma

Research output: Contribution to journalArticle

Abstract

Purpose To evaluate the impact of fluid-attenuated-inversion-recovery MRI (FLAIR/MRI) and Carbon-11-labeled-methionine PET (11C-MET-PET) on high grade glioma (HGG) tumor volume delineation for radiotherapy planning. Material and methods Sixty-nine patients with HGG were evaluated. The clinical target volumes (CTV1, generated by adding a 10 mm margin to FLAIRMRI area, CTV2 by adding a 20 mm margin to enhanced T1MRI) and biological target volume (BTV) were delineated on pre-operative MRI images and 11CMETPET respectively. Results The overlap between CTV1 and CTV2 showed a low correlation between the two volumes with CTV1 not always fully included into the CTV2. In all cases the whole BTV was included into the CTV1, while in 35/69 patients (50%) part of BTV was outside the CTV2 despite larger margins were added. In all cases recurrences were within the CTV1 volume and in 19/38 (50%) partially outside the CTV2. In all patients relapse corresponded to the BTV area. Conclusions Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalRadiotherapy and Oncology
Volume112
Issue number3
DOIs
Publication statusPublished - Sep 1 2014

Fingerprint

Glioma
Radiotherapy
Recurrence
Tumor Burden
carbon-11 methionine

Keywords

  • High grade glioma
  • MET-PET
  • Radiotherapy-planning

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology
  • Medicine(all)

Cite this

@article{6608dd3345fa4f51ba314a0cd4221420,
title = "Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma",
abstract = "Purpose To evaluate the impact of fluid-attenuated-inversion-recovery MRI (FLAIR/MRI) and Carbon-11-labeled-methionine PET (11C-MET-PET) on high grade glioma (HGG) tumor volume delineation for radiotherapy planning. Material and methods Sixty-nine patients with HGG were evaluated. The clinical target volumes (CTV1, generated by adding a 10 mm margin to FLAIRMRI area, CTV2 by adding a 20 mm margin to enhanced T1MRI) and biological target volume (BTV) were delineated on pre-operative MRI images and 11CMETPET respectively. Results The overlap between CTV1 and CTV2 showed a low correlation between the two volumes with CTV1 not always fully included into the CTV2. In all cases the whole BTV was included into the CTV1, while in 35/69 patients (50{\%}) part of BTV was outside the CTV2 despite larger margins were added. In all cases recurrences were within the CTV1 volume and in 19/38 (50{\%}) partially outside the CTV2. In all patients relapse corresponded to the BTV area. Conclusions Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas.",
keywords = "High grade glioma, MET-PET, Radiotherapy-planning",
author = "Pierina Navarria and Giacomo Reggiori and Federico Pessina and Ascolese, {Anna Maria} and Stefano Tomatis and Pietro Mancosu and Francesca Lobefalo and Elena Clerici and Egesta Lopci and Alberto Bizzi and Marco Grimaldi and Arturo Chiti and Matteo Simonelli and Armando Santoro and Lorenzo Bello and Marta Scorsetti",
year = "2014",
month = "9",
day = "1",
doi = "10.1016/j.radonc.2014.09.004",
language = "English",
volume = "112",
pages = "425--429",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma

AU - Navarria, Pierina

AU - Reggiori, Giacomo

AU - Pessina, Federico

AU - Ascolese, Anna Maria

AU - Tomatis, Stefano

AU - Mancosu, Pietro

AU - Lobefalo, Francesca

AU - Clerici, Elena

AU - Lopci, Egesta

AU - Bizzi, Alberto

AU - Grimaldi, Marco

AU - Chiti, Arturo

AU - Simonelli, Matteo

AU - Santoro, Armando

AU - Bello, Lorenzo

AU - Scorsetti, Marta

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Purpose To evaluate the impact of fluid-attenuated-inversion-recovery MRI (FLAIR/MRI) and Carbon-11-labeled-methionine PET (11C-MET-PET) on high grade glioma (HGG) tumor volume delineation for radiotherapy planning. Material and methods Sixty-nine patients with HGG were evaluated. The clinical target volumes (CTV1, generated by adding a 10 mm margin to FLAIRMRI area, CTV2 by adding a 20 mm margin to enhanced T1MRI) and biological target volume (BTV) were delineated on pre-operative MRI images and 11CMETPET respectively. Results The overlap between CTV1 and CTV2 showed a low correlation between the two volumes with CTV1 not always fully included into the CTV2. In all cases the whole BTV was included into the CTV1, while in 35/69 patients (50%) part of BTV was outside the CTV2 despite larger margins were added. In all cases recurrences were within the CTV1 volume and in 19/38 (50%) partially outside the CTV2. In all patients relapse corresponded to the BTV area. Conclusions Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas.

AB - Purpose To evaluate the impact of fluid-attenuated-inversion-recovery MRI (FLAIR/MRI) and Carbon-11-labeled-methionine PET (11C-MET-PET) on high grade glioma (HGG) tumor volume delineation for radiotherapy planning. Material and methods Sixty-nine patients with HGG were evaluated. The clinical target volumes (CTV1, generated by adding a 10 mm margin to FLAIRMRI area, CTV2 by adding a 20 mm margin to enhanced T1MRI) and biological target volume (BTV) were delineated on pre-operative MRI images and 11CMETPET respectively. Results The overlap between CTV1 and CTV2 showed a low correlation between the two volumes with CTV1 not always fully included into the CTV2. In all cases the whole BTV was included into the CTV1, while in 35/69 patients (50%) part of BTV was outside the CTV2 despite larger margins were added. In all cases recurrences were within the CTV1 volume and in 19/38 (50%) partially outside the CTV2. In all patients relapse corresponded to the BTV area. Conclusions Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas.

KW - High grade glioma

KW - MET-PET

KW - Radiotherapy-planning

UR - http://www.scopus.com/inward/record.url?scp=84911005903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911005903&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2014.09.004

DO - 10.1016/j.radonc.2014.09.004

M3 - Article

C2 - 25308182

AN - SCOPUS:84911005903

VL - 112

SP - 425

EP - 429

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

IS - 3

ER -