Abstract
Purpose To evaluate the impact of fluid-attenuated-inversion-recovery MRI (FLAIR/MRI) and Carbon-11-labeled-methionine PET (11C-MET-PET) on high grade glioma (HGG) tumor volume delineation for radiotherapy planning. Material and methods Sixty-nine patients with HGG were evaluated. The clinical target volumes (CTV1, generated by adding a 10 mm margin to FLAIRMRI area, CTV2 by adding a 20 mm margin to enhanced T1MRI) and biological target volume (BTV) were delineated on pre-operative MRI images and 11CMETPET respectively. Results The overlap between CTV1 and CTV2 showed a low correlation between the two volumes with CTV1 not always fully included into the CTV2. In all cases the whole BTV was included into the CTV1, while in 35/69 patients (50%) part of BTV was outside the CTV2 despite larger margins were added. In all cases recurrences were within the CTV1 volume and in 19/38 (50%) partially outside the CTV2. In all patients relapse corresponded to the BTV area. Conclusions Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas.
| Original language | English |
|---|---|
| Pages (from-to) | 425-429 |
| Number of pages | 5 |
| Journal | Radiotherapy and Oncology |
| Volume | 112 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 1 2014 |
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Keywords
- High grade glioma
- MET-PET
- Radiotherapy-planning
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Hematology
- Medicine(all)
Cite this
Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma. / Navarria, Pierina; Reggiori, Giacomo; Pessina, Federico; Ascolese, Anna Maria; Tomatis, Stefano; Mancosu, Pietro; Lobefalo, Francesca; Clerici, Elena; Lopci, Egesta; Bizzi, Alberto; Grimaldi, Marco; Chiti, Arturo; Simonelli, Matteo; Santoro, Armando; Bello, Lorenzo; Scorsetti, Marta.
In: Radiotherapy and Oncology, Vol. 112, No. 3, 01.09.2014, p. 425-429.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma
AU - Navarria, Pierina
AU - Reggiori, Giacomo
AU - Pessina, Federico
AU - Ascolese, Anna Maria
AU - Tomatis, Stefano
AU - Mancosu, Pietro
AU - Lobefalo, Francesca
AU - Clerici, Elena
AU - Lopci, Egesta
AU - Bizzi, Alberto
AU - Grimaldi, Marco
AU - Chiti, Arturo
AU - Simonelli, Matteo
AU - Santoro, Armando
AU - Bello, Lorenzo
AU - Scorsetti, Marta
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Purpose To evaluate the impact of fluid-attenuated-inversion-recovery MRI (FLAIR/MRI) and Carbon-11-labeled-methionine PET (11C-MET-PET) on high grade glioma (HGG) tumor volume delineation for radiotherapy planning. Material and methods Sixty-nine patients with HGG were evaluated. The clinical target volumes (CTV1, generated by adding a 10 mm margin to FLAIRMRI area, CTV2 by adding a 20 mm margin to enhanced T1MRI) and biological target volume (BTV) were delineated on pre-operative MRI images and 11CMETPET respectively. Results The overlap between CTV1 and CTV2 showed a low correlation between the two volumes with CTV1 not always fully included into the CTV2. In all cases the whole BTV was included into the CTV1, while in 35/69 patients (50%) part of BTV was outside the CTV2 despite larger margins were added. In all cases recurrences were within the CTV1 volume and in 19/38 (50%) partially outside the CTV2. In all patients relapse corresponded to the BTV area. Conclusions Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas.
AB - Purpose To evaluate the impact of fluid-attenuated-inversion-recovery MRI (FLAIR/MRI) and Carbon-11-labeled-methionine PET (11C-MET-PET) on high grade glioma (HGG) tumor volume delineation for radiotherapy planning. Material and methods Sixty-nine patients with HGG were evaluated. The clinical target volumes (CTV1, generated by adding a 10 mm margin to FLAIRMRI area, CTV2 by adding a 20 mm margin to enhanced T1MRI) and biological target volume (BTV) were delineated on pre-operative MRI images and 11CMETPET respectively. Results The overlap between CTV1 and CTV2 showed a low correlation between the two volumes with CTV1 not always fully included into the CTV2. In all cases the whole BTV was included into the CTV1, while in 35/69 patients (50%) part of BTV was outside the CTV2 despite larger margins were added. In all cases recurrences were within the CTV1 volume and in 19/38 (50%) partially outside the CTV2. In all patients relapse corresponded to the BTV area. Conclusions Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas.
KW - High grade glioma
KW - MET-PET
KW - Radiotherapy-planning
UR - http://www.scopus.com/inward/record.url?scp=84911005903&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84911005903&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2014.09.004
DO - 10.1016/j.radonc.2014.09.004
M3 - Article
C2 - 25308182
AN - SCOPUS:84911005903
VL - 112
SP - 425
EP - 429
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
SN - 0167-8140
IS - 3
ER -