Investigational agents against platinum-resistant ovarian cancer

Domenica Lorusso, Gabriella Ferrandina, Francesco Fanfani, Maria Lucia Gagliardi, Giovanni Scambia

Research output: Contribution to journalArticlepeer-review

Abstract

Ovarian cancer is still the fourth cause of death by cancer among women and is the most fatal among gynaecological tumours. The goal of treatment for patients with recurrent, platinum-resistant (platinum-free interval <6 months) ovarian cancer is the palliation of symptoms because no evidence indicates that present therapies may prolong survival in this setting of patients. Successful management of these patients depends on the identification of agents that are not cross-resistant with platinum compounds. The development of molecular biology is providing us with new information on the molecular basis of cancer, its mechanism of initiation and progression, and supply the need of a more patient-tailored therapy where specific turnours are treated with specific drugs. This paper reports and discusses new developments in the treatment of platinum-resistant ovarian cancer patients. The authors present proteomic advances, including the HER kinases, the 26S proteasome and the angiogenesis pathway. The opportunities to change the treatment of ovarian cancer will require creative clinical trial design but the next 10 years promise to be filled with therapeutic advances for patients with ovarian cancer.

Original languageEnglish
Pages (from-to)325-336
Number of pages12
JournalExpert Opinion on Investigational Drugs
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • Antiangiogenetic agents
  • Molecular biology
  • Ovarian cancer
  • Platinum resistance

ASJC Scopus subject areas

  • Pharmacology

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