Invisible dermatoses from the perspective of the dermatopathologist: New observations

Carlo Tomasini

Research output: Contribution to journalReview articlepeer-review


The term "invisible dermatoses" is often used in two different contexts: 1) dermatoses which are invisible to the clinician, i.e., diseases with no significant clinical features; 2) dermatoses which are invisible to the pathologist. These latter comprise a wide spectrum of entities which present with definite and obvious clinical features, but subtle or hidden histological features and are therefore "invisible" histologically. Diagnosis of such diseases represents a great challenge to both the dermatologist and dermatopathologist. The list of such diseases, originally comprising only few entities, has been gradually expanded over decades and now is a large one. This review focuses on the recently expanded spectrum of such diseases, and offers to the dermatopathologist a strategy for their diagnosis, based mainly on proper awareness, recognition of subtle features, special stains, special investigations such as immunofluorescence and histochemistry and proper clinicopathological correlation.

Original languageEnglish
Pages (from-to)500-515
Number of pages16
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number5
Publication statusPublished - Oct 1 2017
Externally publishedYes


  • Diagnosis
  • Hemosiderosis
  • Hydroxyurea
  • Pathology
  • Skin diseases

ASJC Scopus subject areas

  • Dermatology


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