Involucrin expression in keratinization disorders of the skin - a preliminary study

J. Kanitakis, G. Zambruno, J. Viac, J. Thivolet

Research output: Contribution to journalArticle

Abstract

We have studied the expression of involucrin in a variety of keratinization disorders, mostly of genetic origin using an avidin-biotin-peroxidase technique. In normal human epidermis 25% of the living epidermis was labelled. The diseases studied fell into two groups. Diseases with greatly increased involucrin staining including collodion baby (38%), Darier's disease (49%), Flegel's disease (56%), erythrokeratoderma variabilis (60%), epidermal naevus with epidermolytic hyperkeratosis (45%) and congenital bullous (58%) and non-bullous (44%) ichthyosiform erythroderma; and diseases with normal or slightly increased staining, including ichthyosis vulgaris (27%), X-linked ichthyosis (25%), confluent and reticulate papillomatosis (27%) and simple epidermal naevus (28%). These results demonstrate that involucrin expression is altered in some keratinization disorders and suggest that in such conditions cellular functions other than keratin metabolism are also affected.

Original languageEnglish
Pages (from-to)479-486
Number of pages8
JournalBritish Journal of Dermatology
Volume117
Issue number4
Publication statusPublished - 1987

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Epidermis
Skin
Ichthyosis Vulgaris
Epidermolytic Hyperkeratosis
X-Linked Ichthyosis
Darier Disease
Staining and Labeling
Exfoliative Dermatitis
Inborn Genetic Diseases
Collodion
Avidin
Papilloma
Biotin
Keratins
Peroxidase
involucrin
Epidermal Nevus
Hyperkeratosis lenticularis perstans

ASJC Scopus subject areas

  • Dermatology

Cite this

Involucrin expression in keratinization disorders of the skin - a preliminary study. / Kanitakis, J.; Zambruno, G.; Viac, J.; Thivolet, J.

In: British Journal of Dermatology, Vol. 117, No. 4, 1987, p. 479-486.

Research output: Contribution to journalArticle

Kanitakis, J. ; Zambruno, G. ; Viac, J. ; Thivolet, J. / Involucrin expression in keratinization disorders of the skin - a preliminary study. In: British Journal of Dermatology. 1987 ; Vol. 117, No. 4. pp. 479-486.
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