Involvement of 5-lipoxygenase in Alzheimer's disease: A role for DNA methylation

Andrea Di Francesco, Beatrice Arosio, Cristina Gussago, Enrico Dainese, Daniela Mari, Claudio D'Addario, Mauro MacCarrone

Research output: Contribution to journalArticlepeer-review


Lipoxygenases play a major role in the neuropathology of Alzheimer's disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. We found a significant increase in 5-LOX gene expression in AD subjects compared to healthy controls, paralleled by increased 5-LOX protein and leukotriene B4, the 5-LOX product. In addition, a consistent reduction in DNA methylation at 5-LOX gene promoter was documented in AD versus healthy subjects. Taken together, our findings further support a role for 5-LOX in vulnerability to neurodegeneration.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalJournal of Alzheimer's Disease
Issue number1
Publication statusPublished - 2013


  • 5-lipoxygenase
  • Alzheimer's disease
  • biomarker
  • DNA methylation
  • fatty acid amide hydrolase
  • peripheral blood mononuclear cells

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology


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