Abstract
Lipoxygenases play a major role in the neuropathology of Alzheimer's disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. We found a significant increase in 5-LOX gene expression in AD subjects compared to healthy controls, paralleled by increased 5-LOX protein and leukotriene B4, the 5-LOX product. In addition, a consistent reduction in DNA methylation at 5-LOX gene promoter was documented in AD versus healthy subjects. Taken together, our findings further support a role for 5-LOX in vulnerability to neurodegeneration.
Original language | English |
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Pages (from-to) | 3-8 |
Number of pages | 6 |
Journal | Journal of Alzheimer's Disease |
Volume | 37 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- 5-lipoxygenase
- Alzheimer's disease
- biomarker
- DNA methylation
- fatty acid amide hydrolase
- peripheral blood mononuclear cells
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Clinical Psychology