Involvement of brain histamine in basal and stress-induced release of prolactin in the rat

C. Netti, F. Guidobono, V. Sibilia, I. Villa, E. Cazzamalli, A. Pecile

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated whether inhibition of brain histamine (HA) synthesis by α-fluoromethylhistidine (α-FMH) can influence basal or stimulated prolactin (PRL) release in male rats. α-FMH was administered either into the carotid (i.a., 20 and 100 mg/kg) or intracerebroventriculary (i.c.v., 200 μg/rat) into freely moving rats with indwelling catheters. Plasma PRL levels were measured 90, 120, 180 min later. Both i.a. and i.c.v. administration of α-FMH significantly inhibited basal PRL secretion at 120 and 180 min. When PRL secretion was stimulated by exposing rats to restraint stress, α-FMH administered 3 h before the stress (20 and 100 mg/kg, i.a.; 200 μg/rat, i.c.v.) was able to prevent the PRL surges at 10 and 20 min after stress. These results suggest that endogenous brain HA has a facilitatory role in the control of PRL secretion in rats.

Original languageEnglish
Pages (from-to)236-238
Number of pages3
JournalAgents and Actions
Volume20
Issue number3-4
DOIs
Publication statusPublished - Apr 1987

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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