Involvement of catecholaminergic transmission in neurophysiological responses to centrally administered NPY.

M. Maurelli; E. Marchioni; A. Tartara

Involvement of catecholaminergic transmission in neurophysiological responses to centrally administered NPY.

M. Maurelli, E. Marchioni, A. Tartara

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of centrally administered NPY on the EEG, somatic behaviour and some autonomic parameters have been studied in unanesthetized rabbit. In this species the peptide induces EEG and behavioural sedative effects similar to those described in the awake rat, but do not cause hypotension, bradycardia and bradypnea. The EEG pattern seems to be independent from the monoaminergic transmission, while the behavioural sedation is reversed by the alpha 2-adrenergic antagonist yohimbine.

Original language	English
Pages (from-to)	187-193
Number of pages	7
Journal	Bollettino della Societa Italiana di Biologia Sperimentale
Volume	69
Issue number	3
Publication status	Published - Mar 1993

ASJC Scopus subject areas

Medicine(all)

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abstract = "The effects of centrally administered NPY on the EEG, somatic behaviour and some autonomic parameters have been studied in unanesthetized rabbit. In this species the peptide induces EEG and behavioural sedative effects similar to those described in the awake rat, but do not cause hypotension, bradycardia and bradypnea. The EEG pattern seems to be independent from the monoaminergic transmission, while the behavioural sedation is reversed by the alpha 2-adrenergic antagonist yohimbine.",

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