TY - JOUR
T1 - Involvement of CD56/N-CAM molecule in the adhesion of human solid tumor cell lines to endothelial cells
AU - Zocchi, M. R.
AU - Vidal, M.
AU - Poggi, A.
PY - 1993
Y1 - 1993
N2 - Tumor-endothelial cell adhesion has been investigated, as this event might represent one of the first steps in the generation of tumor metastasis. We focused our attention on the N-CAM homologous CD56 (besides the CD44, CD15, and CDw49d antigens), as we have recently reported that it can mediate lymphocyte-endothelial cell adhesion. Herein we show that CD56 is involved in tumor cell-endothelial cell binding. This phenomenon is independent of Ca2+ and unlikely to be influenced by the degree of CD56 sialylation.
AB - Tumor-endothelial cell adhesion has been investigated, as this event might represent one of the first steps in the generation of tumor metastasis. We focused our attention on the N-CAM homologous CD56 (besides the CD44, CD15, and CDw49d antigens), as we have recently reported that it can mediate lymphocyte-endothelial cell adhesion. Herein we show that CD56 is involved in tumor cell-endothelial cell binding. This phenomenon is independent of Ca2+ and unlikely to be influenced by the degree of CD56 sialylation.
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U2 - 10.1006/excr.1993.1017
DO - 10.1006/excr.1993.1017
M3 - Article
C2 - 7677984
AN - SCOPUS:0027181022
VL - 204
SP - 130
EP - 135
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 1
ER -