Tumor-endothelial cell adhesion has been investigated, as this event might represent one of the first steps in the generation of tumor metastasis. We focused our attention on the N-CAM homologous CD56 (besides the CD44, CD15, and CDw49d antigens), as we have recently reported that it can mediate lymphocyte-endothelial cell adhesion. Herein we show that CD56 is involved in tumor cell-endothelial cell binding. This phenomenon is independent of Ca2+ and unlikely to be influenced by the degree of CD56 sialylation.
ASJC Scopus subject areas
- Cell Biology