TY - JOUR
T1 - Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus
T2 - A source localization EEG study
AU - Houdayer, E.
AU - Teggi, R.
AU - Velikova, S.
AU - Gonzalez-Rosa, J. J.
AU - Bussi, M.
AU - Comi, G.
AU - Leocani, L.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Objective: To better characterize brain circuits dysfunctions in normoacousic tinnitus sufferers. Methods: 17 normoacousic chronic, unilateral high-pitched tinnitus sufferers (6 females, 43.6. ±9.8. y.o, disease duration 22. ±35. months) underwent a 29-channel resting-state electroencephalography (EEG - 5. min opened-eyes, 5. min closed-eyes) and auditory oddball paradigm for event-related potentials analyses (ERPs - N1, P2 and P300). Cortical 3D distribution of current source density was computed with sLORETA. Results were compared with 17 controls (9 females, 45.7±15.1. y.o). Results: Eyes opened, tinnitus sufferers had lower alpha and beta sources in the left inferior parietal lobule. Eyes closed, tinnitus sufferers had decreased alpha sources in the left inferior temporal and post-central gyri, and low gamma sources in the left middle temporal gyrus. EEG data did not correlate with tinnitus sufferers' clinical features. Subjects with tinnitus had shorter N1 and P2 latencies. P300 did not differ between groups. sLORETA solutions showed decreased sources of these ERPs in the left inferior temporal gyrus in the tinnitus group. Conclusions: We showed cortico-thalamo-cortical involvements in normoacousic tinnitus with hyperexcitability of the left auditory cortex and inferior temporal gyrus. Significance: This might reflect processes of maladaptive cortical plasticity and memory consolidation. Further validation is needed to establish the value of this tool in customizing therapeutic approach.
AB - Objective: To better characterize brain circuits dysfunctions in normoacousic tinnitus sufferers. Methods: 17 normoacousic chronic, unilateral high-pitched tinnitus sufferers (6 females, 43.6. ±9.8. y.o, disease duration 22. ±35. months) underwent a 29-channel resting-state electroencephalography (EEG - 5. min opened-eyes, 5. min closed-eyes) and auditory oddball paradigm for event-related potentials analyses (ERPs - N1, P2 and P300). Cortical 3D distribution of current source density was computed with sLORETA. Results were compared with 17 controls (9 females, 45.7±15.1. y.o). Results: Eyes opened, tinnitus sufferers had lower alpha and beta sources in the left inferior parietal lobule. Eyes closed, tinnitus sufferers had decreased alpha sources in the left inferior temporal and post-central gyri, and low gamma sources in the left middle temporal gyrus. EEG data did not correlate with tinnitus sufferers' clinical features. Subjects with tinnitus had shorter N1 and P2 latencies. P300 did not differ between groups. sLORETA solutions showed decreased sources of these ERPs in the left inferior temporal gyrus in the tinnitus group. Conclusions: We showed cortico-thalamo-cortical involvements in normoacousic tinnitus with hyperexcitability of the left auditory cortex and inferior temporal gyrus. Significance: This might reflect processes of maladaptive cortical plasticity and memory consolidation. Further validation is needed to establish the value of this tool in customizing therapeutic approach.
KW - Electroencephalography
KW - Event-related potentials
KW - Resting state
KW - SLORETA
KW - Tinnitus
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U2 - 10.1016/j.clinph.2015.01.027
DO - 10.1016/j.clinph.2015.01.027
M3 - Article
C2 - 25753907
AN - SCOPUS:84948714828
VL - 126
SP - 2356
EP - 2365
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 12
ER -