Abstract
Platelet-activating factor (PAF) is a phospholipid that exhibits a wide range of biological activities as a secondary mediator of inflammation and anphylaxis. Primary mediators of inflammation, such as interleukin-1 and tumor necrosis factor, stimulate PAF release by monocytes/macrophages, neutrophils and endothelial cells. PAF has also been implicated in cell-mediated hypersensitivity reactions. This review will focus on recent dats suggesting that the local production of these mediators in glomeruli by infiltrating inflammatory cells or resident cells may influence the clinicopathological expression of glomerular disease. Results from in vitro and experimental studies suggest that these mediators alter the growth pattern of glomerular cells and the composition of secreted matrix, leading to scar formation and eventually to glomerulosclerosis.
| Original language | English |
|---|---|
| Journal | Journal of Lipid Mediators |
| Volume | 2 |
| Issue number | SUPPL. |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Immunology
- Pharmacology
Cite this
Involvement of cytokines and platelet-activating factor in renal pathology. / Gamussi, G.; Tetta, C.; Bussolino, F.; Andres, G.; Turello, E.; Bag lioni, C.
In: Journal of Lipid Mediators, Vol. 2, No. SUPPL., 1990.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Involvement of cytokines and platelet-activating factor in renal pathology
AU - Gamussi, G.
AU - Tetta, C.
AU - Bussolino, F.
AU - Andres, G.
AU - Turello, E.
AU - Bag lioni, C.
PY - 1990
Y1 - 1990
N2 - Platelet-activating factor (PAF) is a phospholipid that exhibits a wide range of biological activities as a secondary mediator of inflammation and anphylaxis. Primary mediators of inflammation, such as interleukin-1 and tumor necrosis factor, stimulate PAF release by monocytes/macrophages, neutrophils and endothelial cells. PAF has also been implicated in cell-mediated hypersensitivity reactions. This review will focus on recent dats suggesting that the local production of these mediators in glomeruli by infiltrating inflammatory cells or resident cells may influence the clinicopathological expression of glomerular disease. Results from in vitro and experimental studies suggest that these mediators alter the growth pattern of glomerular cells and the composition of secreted matrix, leading to scar formation and eventually to glomerulosclerosis.
AB - Platelet-activating factor (PAF) is a phospholipid that exhibits a wide range of biological activities as a secondary mediator of inflammation and anphylaxis. Primary mediators of inflammation, such as interleukin-1 and tumor necrosis factor, stimulate PAF release by monocytes/macrophages, neutrophils and endothelial cells. PAF has also been implicated in cell-mediated hypersensitivity reactions. This review will focus on recent dats suggesting that the local production of these mediators in glomeruli by infiltrating inflammatory cells or resident cells may influence the clinicopathological expression of glomerular disease. Results from in vitro and experimental studies suggest that these mediators alter the growth pattern of glomerular cells and the composition of secreted matrix, leading to scar formation and eventually to glomerulosclerosis.
UR - http://www.scopus.com/inward/record.url?scp=0025219533&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025219533&partnerID=8YFLogxK
M3 - Article
C2 - 2133283
AN - SCOPUS:0025219533
VL - 2
JO - Journal of Lipid Mediators
JF - Journal of Lipid Mediators
SN - 0921-8319
IS - SUPPL.
ER -