Involvement of D-aspartic acid in the synthesis of testosterone in rat testes

Antimo D'Aniello, Anna Di Cosmo, Carlo Di Cristo, Lucio Annunziato, Leonard Petrucelli, George Fisher

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

D-Aspartic acid (D-Asp) is an endogenous amino acid which occurs in many marine and terrestrial animals. In fetal and young rats, this amino acid occurs prevalently in nervous tissue, whereas at sexual maturity it occurs in endocrine glands and above all in pituitary and testes. Here, we have studied if a relationship exists between the presence of D-Asp and the hormonal activity. The following results were obtained: 1) Both D-Asp and testosterone are synthesized in rat testes in two periods of the animal's life: before birth, about the 17th day after fertilization and, after birth, at sexual maturity. 2) Immunocytochemical studies have demonstrated that this enantiomer is localized in Leydig and Sertoli cells. 3) In vivo experiments, consisting of i.p. injection of D-Asp to adult male rats, demonstrated that this amino acid accumulates in pituitary and testis (after 5 h, the accumulation was 12 and 4-fold over basal values, respectively); simultaneously, luteinizing hormone, testosterone and progesterone significantly increased in the blood (1.6-fold, p

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalLife Sciences
Volume59
Issue number2
DOIs
Publication statusPublished - Jul 7 1996

Fingerprint

D-Aspartic Acid
Testosterone
Testis
Rats
Amino Acids
Animals
Parturition
Endocrine Glands
Nerve Tissue
Enantiomers
Leydig Cells
Sertoli Cells
Luteinizing Hormone
Fertilization
Progesterone
Blood
Tissue
Injections
Experiments

Keywords

  • D-aspartic acid
  • hormones
  • luteinizing hormone
  • steroidogenesis
  • testes
  • testosterone

ASJC Scopus subject areas

  • Pharmacology

Cite this

D'Aniello, A., Di Cosmo, A., Di Cristo, C., Annunziato, L., Petrucelli, L., & Fisher, G. (1996). Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. Life Sciences, 59(2), 97-104. https://doi.org/10.1016/0024-3205(96)00266-4

Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. / D'Aniello, Antimo; Di Cosmo, Anna; Di Cristo, Carlo; Annunziato, Lucio; Petrucelli, Leonard; Fisher, George.

In: Life Sciences, Vol. 59, No. 2, 07.07.1996, p. 97-104.

Research output: Contribution to journalArticle

D'Aniello, A, Di Cosmo, A, Di Cristo, C, Annunziato, L, Petrucelli, L & Fisher, G 1996, 'Involvement of D-aspartic acid in the synthesis of testosterone in rat testes', Life Sciences, vol. 59, no. 2, pp. 97-104. https://doi.org/10.1016/0024-3205(96)00266-4
D'Aniello, Antimo ; Di Cosmo, Anna ; Di Cristo, Carlo ; Annunziato, Lucio ; Petrucelli, Leonard ; Fisher, George. / Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. In: Life Sciences. 1996 ; Vol. 59, No. 2. pp. 97-104.
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