Involvement of endothelial PECAM-1/CD31 in angiogenesis

Horace M. DeLisser, Melpo Christofidou-Solomidou, Robert M. Strieter, Marie D. Burdick, Candy S. Robinson, Roseanne S. Wexler, Janet S. Kerr, Cecilia Garlanda, June R. Merwin, Joseph A. Madri, Steven M. Albelda

Research output: Contribution to journalArticlepeer-review

Abstract

The adhesive interactions of endothelial cells with each other and the adhesion receptors that mediate these interactions are probably of fundamental importance to the process of angiogenesis. We therefore studied the effect of inhibiting the function of the endothelial cell-cell adhesion molecule, PECAM-1/CD31, in rat and murine models of angiogenesis. A polyclonal antibody to human PECAM-1, which crossreacts with rat PECAM-1, was found to block in vitro tube formation by rat capillary endothelial cells and cytokine-induced rat corneal neovascularization. In mice, two monoclonal antibodies against murine PECAM-1 prevented vessel growth into subcutaneously implanted gels supplemented with basic fibroblast growth factor (bFGF). Taken together these findings provide evidence that PECAM-1 is involved in angiogenesis and suggest that the interactions of endothelial cell-cell adhesion molecules are important in the formation of new vessels.

Original languageEnglish
Pages (from-to)671-677
Number of pages7
JournalAmerican Journal of Pathology
Volume151
Issue number3
Publication statusPublished - Sep 1997

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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