Involvement of Fas/FasL system in the pathogenesis of autoimmune diseases and Wilson's disease

Giorgio Stassi, Valentina Di Felice, Matilde Todaro, Francesco Cappello, Giovanni Zummo, Felicia Farina, Massimo Trucco, Ruggero De Maria

Research output: Contribution to journalArticlepeer-review

Abstract

The interaction of Fas with FasL has been demonstrated to be implicated in the pathogenesis of several autoimmune and liver diseases. Recently, attention has been focused on the hypothesis that thyrocytes and β cells undergo massive Fas/FasL-mediated apoptosis during autoimmune response. Similarly, hepatocyte cell death occurring following copper accumulation points towards the same mechanism.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume47
Issue number3
Publication statusPublished - 1999

Keywords

  • Apoptosis
  • Autoimmune diseases
  • Fas
  • Hashimoto's thyroiditis
  • Insulin-dependent diabetes mellitus
  • Wilson's disease

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Involvement of Fas/FasL system in the pathogenesis of autoimmune diseases and Wilson's disease'. Together they form a unique fingerprint.

Cite this