Involvement of hormonal circadian secretion in the growth of HIV-infected children

Mariangela Rondanelli, Desiree Caselli, Anna Maccabruni, Mohamed Maghnie, Luisa Bacchella, Anna DeStefano, Sebastiano B. Solerte, Lorenzo Minoli, Ettore Ferrari

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To evaluate the circadian secretion of hormones involved in the regulation of growth in childhood, namely growth hormone, insulin-like growth factor (IGF)-I, cortisol, adrenocorticotropin hormone (ACTH), and thyroid-stimulating hormone (TSH) in HIV-infected children. Design: The circadian secretory pattern of growth hormone, IGF-I, cortisol, ACTH and TSH was evaluated in 14 HIV-infected children; 13 healthy age- and sex-matched children were chosen as controls. Methods: Sampling was performed every 4 h from 0400 h to 2000 h and every 2 h from 2000 h to 0400 h. Rhythmometric data were analysed by single and population mean cosinor methods and by analysis of variance. Results: A statistically significant circadian rhythm for growth hormone, IGF-I and cortisol was detectable in HIV-seropositive children, but the mean basal IGF-I levels were below the normal range for age in 12 patients. A statistically significant circadian rhythm was not detectable for ACTH or TSH. Conclusion: These results show that there is a loss of the physiological regulation of growth hormone-IGF-I axis and a modification of 24 h TSH profile in our HIV-infected children. These abnormalities might be involved in the altered growth mechanism leading to the failure to thrive that is a peculiar feature of HIV-infected children.

Original languageEnglish
Pages (from-to)1845-1850
Number of pages6
JournalAIDS (London, England)
Volume12
Issue number14
Publication statusPublished - Oct 1 1998

Fingerprint

Insulin-Like Growth Factor I
HIV
Thyrotropin
Growth Hormone
Growth
Hormones
Adrenocorticotropic Hormone
Hydrocortisone
Circadian Rhythm
Failure to Thrive
Analysis of Variance
Reference Values
Population

Keywords

  • Adrenocorticotropin hormone
  • AIDS
  • Cortisol
  • Growth hormone
  • Hormonal circadian rhythm
  • Insulin-like growth factor-I
  • Thyroid-stimulating hormone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Rondanelli, M., Caselli, D., Maccabruni, A., Maghnie, M., Bacchella, L., DeStefano, A., ... Ferrari, E. (1998). Involvement of hormonal circadian secretion in the growth of HIV-infected children. AIDS (London, England), 12(14), 1845-1850.

Involvement of hormonal circadian secretion in the growth of HIV-infected children. / Rondanelli, Mariangela; Caselli, Desiree; Maccabruni, Anna; Maghnie, Mohamed; Bacchella, Luisa; DeStefano, Anna; Solerte, Sebastiano B.; Minoli, Lorenzo; Ferrari, Ettore.

In: AIDS (London, England), Vol. 12, No. 14, 01.10.1998, p. 1845-1850.

Research output: Contribution to journalArticle

Rondanelli, M, Caselli, D, Maccabruni, A, Maghnie, M, Bacchella, L, DeStefano, A, Solerte, SB, Minoli, L & Ferrari, E 1998, 'Involvement of hormonal circadian secretion in the growth of HIV-infected children', AIDS (London, England), vol. 12, no. 14, pp. 1845-1850.
Rondanelli M, Caselli D, Maccabruni A, Maghnie M, Bacchella L, DeStefano A et al. Involvement of hormonal circadian secretion in the growth of HIV-infected children. AIDS (London, England). 1998 Oct 1;12(14):1845-1850.
Rondanelli, Mariangela ; Caselli, Desiree ; Maccabruni, Anna ; Maghnie, Mohamed ; Bacchella, Luisa ; DeStefano, Anna ; Solerte, Sebastiano B. ; Minoli, Lorenzo ; Ferrari, Ettore. / Involvement of hormonal circadian secretion in the growth of HIV-infected children. In: AIDS (London, England). 1998 ; Vol. 12, No. 14. pp. 1845-1850.
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