Involvement of hormonal circadian secretion in the growth of HIV-infected children

Mariangela Rondanelli, Desiree Caselli, Anna Maccabruni, Mohamed Maghnie, Luisa Bacchella, Anna DeStefano, Sebastiano B. Solerte, Lorenzo Minoli, Ettore Ferrari

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate the circadian secretion of hormones involved in the regulation of growth in childhood, namely growth hormone, insulin-like growth factor (IGF)-I, cortisol, adrenocorticotropin hormone (ACTH), and thyroid-stimulating hormone (TSH) in HIV-infected children. Design: The circadian secretory pattern of growth hormone, IGF-I, cortisol, ACTH and TSH was evaluated in 14 HIV-infected children; 13 healthy age- and sex-matched children were chosen as controls. Methods: Sampling was performed every 4 h from 0400 h to 2000 h and every 2 h from 2000 h to 0400 h. Rhythmometric data were analysed by single and population mean cosinor methods and by analysis of variance. Results: A statistically significant circadian rhythm for growth hormone, IGF-I and cortisol was detectable in HIV-seropositive children, but the mean basal IGF-I levels were below the normal range for age in 12 patients. A statistically significant circadian rhythm was not detectable for ACTH or TSH. Conclusion: These results show that there is a loss of the physiological regulation of growth hormone-IGF-I axis and a modification of 24 h TSH profile in our HIV-infected children. These abnormalities might be involved in the altered growth mechanism leading to the failure to thrive that is a peculiar feature of HIV-infected children.

Original languageEnglish
Pages (from-to)1845-1850
Number of pages6
JournalAIDS (London, England)
Issue number14
Publication statusPublished - Oct 1 1998


  • Adrenocorticotropin hormone
  • AIDS
  • Cortisol
  • Growth hormone
  • Hormonal circadian rhythm
  • Insulin-like growth factor-I
  • Thyroid-stimulating hormone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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