Involvement of mast cells in angiogenesis and chronic inflammation

Enrico Crivellato, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Mast cells (MC) are granulated secretory cells that have long been recognized as a rich source of biologically highly active mediators such as biogenic amines, prostaglandins, leukotrienes, proteases, cytokines and chemokines. Most of their biological functions however has been rather elusive. There are now emerging data assigning these cells a relevant role in orchestrating angiogenesis, both in normal and pathological conditions. MC indeed synthesize and release a large array of proangiogenic factors upon different stimulation pathways. In addition, MC have been recognized as key cells in mediating host innate and adaptive immune responses. This review summarizes the most recent acquisitions concerning MC involvement in angiogenic processes and chronic inflammatory reactions.

Original languageEnglish
Pages (from-to)9-11
Number of pages3
JournalCurrent Drug Targets: Inflammation and Allergy
Volume4
Issue number1
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Angiogenesis
  • Cytokines
  • Human pathology
  • Inflammation
  • Mast cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

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