Involvement of Mediator complex in malignancy

Concetta Schiano, Amelia Casamassimi, Monica Rienzo, Filomena de Nigris, Linda Sommese, Claudio Napoli

Research output: Contribution to journalArticle

Abstract

Mediator complex (MED) is an evolutionarily conserved multiprotein, fundamental for growth and survival of all cells. In eukaryotes, the mRNA transcription is dependent on RNA polymerase II that is associated to various molecules like general transcription factors, MED subunits and chromatin regulators. To date, transcriptional machinery dysfunction has been shown to elicit broad effects on cell proliferation, development, differentiation, and pathologic disease induction, including cancer. Indeed, in malignant cells, the improper activation of specific genes is usually ascribed to aberrant transcription machinery. Here, we focus our attention on the correlation of MED subunits with carcinogenesis. To date, many subunits are mutated or display altered expression in human cancers. Particularly, the role of MED1, MED28, MED12, CDK8 and Cyclin C in cancer is well documented, although several studies have recently reported a possible association of other subunits with malignancy. Definitely, a major comprehension of the involvement of the whole complex in cancer may lead to the identification of MED subunits as novel diagnostic/prognostic tumour markers to be used in combination with imaging technique in clinical oncology, and to develop novel anti-cancer targets for molecular-targeted therapy.

Original languageEnglish
Pages (from-to)66-83
Number of pages18
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1845
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Biomarkers
  • Cancer
  • Mediator complex
  • Transcription
  • Tumorigenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

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