Involvement of non melanocytic skin cells in vitiligo

Research output: Contribution to journalReview article

Abstract

Despite melanocytes are the key players in vitiligo, a continuous cross-talk between epidermal and dermal cells may strictly affect their functionality, in both lesional and non-lesional skin. Focusing on this interplay, we have reviewed existing literature supporting evidence on cellular and functional alterations of surrounding epidermal keratinocytes, extracellular matrix (ECM) proteins and fibroblasts in the underlying dermal compartment that may contribute to melanocyte disappearance in vitiligo. We have also examined some clinical and therapeutic aspects of the disease to sustain the non-exclusive involvement of melanocytes within vitiligo. As a result, a different and more complex scenario has appeared that may enable to provide better understanding about origins and progress of vitiligo and that should be considered in the evaluation of new treatment approaches. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalExperimental Dermatology
DOIs
Publication statusE-pub ahead of print - Dec 24 2018

Fingerprint

Vitiligo
Extracellular Matrix Proteins
Fibroblasts
Melanocytes
Skin
Keratinocytes
Therapeutics

Cite this

@article{5d483ec9c6a447ba82fff208fc5f14c0,
title = "Involvement of non melanocytic skin cells in vitiligo",
abstract = "Despite melanocytes are the key players in vitiligo, a continuous cross-talk between epidermal and dermal cells may strictly affect their functionality, in both lesional and non-lesional skin. Focusing on this interplay, we have reviewed existing literature supporting evidence on cellular and functional alterations of surrounding epidermal keratinocytes, extracellular matrix (ECM) proteins and fibroblasts in the underlying dermal compartment that may contribute to melanocyte disappearance in vitiligo. We have also examined some clinical and therapeutic aspects of the disease to sustain the non-exclusive involvement of melanocytes within vitiligo. As a result, a different and more complex scenario has appeared that may enable to provide better understanding about origins and progress of vitiligo and that should be considered in the evaluation of new treatment approaches. This article is protected by copyright. All rights reserved.",
author = "Emanuela Bastonini and Barbara Bellei and Angela Filoni and Daniela Kovacs and Paolo Iacovelli and Mauro Picardo",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
month = "12",
day = "24",
doi = "10.1111/exd.13868",
language = "English",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Involvement of non melanocytic skin cells in vitiligo

AU - Bastonini, Emanuela

AU - Bellei, Barbara

AU - Filoni, Angela

AU - Kovacs, Daniela

AU - Iacovelli, Paolo

AU - Picardo, Mauro

N1 - This article is protected by copyright. All rights reserved.

PY - 2018/12/24

Y1 - 2018/12/24

N2 - Despite melanocytes are the key players in vitiligo, a continuous cross-talk between epidermal and dermal cells may strictly affect their functionality, in both lesional and non-lesional skin. Focusing on this interplay, we have reviewed existing literature supporting evidence on cellular and functional alterations of surrounding epidermal keratinocytes, extracellular matrix (ECM) proteins and fibroblasts in the underlying dermal compartment that may contribute to melanocyte disappearance in vitiligo. We have also examined some clinical and therapeutic aspects of the disease to sustain the non-exclusive involvement of melanocytes within vitiligo. As a result, a different and more complex scenario has appeared that may enable to provide better understanding about origins and progress of vitiligo and that should be considered in the evaluation of new treatment approaches. This article is protected by copyright. All rights reserved.

AB - Despite melanocytes are the key players in vitiligo, a continuous cross-talk between epidermal and dermal cells may strictly affect their functionality, in both lesional and non-lesional skin. Focusing on this interplay, we have reviewed existing literature supporting evidence on cellular and functional alterations of surrounding epidermal keratinocytes, extracellular matrix (ECM) proteins and fibroblasts in the underlying dermal compartment that may contribute to melanocyte disappearance in vitiligo. We have also examined some clinical and therapeutic aspects of the disease to sustain the non-exclusive involvement of melanocytes within vitiligo. As a result, a different and more complex scenario has appeared that may enable to provide better understanding about origins and progress of vitiligo and that should be considered in the evaluation of new treatment approaches. This article is protected by copyright. All rights reserved.

U2 - 10.1111/exd.13868

DO - 10.1111/exd.13868

M3 - Review article

C2 - 30582762

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

ER -