Involvement of target gene polymorphisms in 5-fluorouracil toxicity: A case report

Anna Scalvini, Vittorio Ferrari, Serena Bodei, Giuseppina Arcangeli, Francesca Consoli, PierFranco Spano, Sandra Sigala

Research output: Contribution to journalArticlepeer-review

Abstract

Personalized medicine is becoming an important tool in oncology, both in preventing disease and in optimizing the treatment of existing cancers. Here we describe the cases of 2 patients with relevant systemic toxicity following 5-fluorouracil (5-FU) therapy and we study the more frequent polymorphisms in the target genes, in particular: (1) the variability in the number of 28-base repetitions present in the 5′-untranslated sequence of the thymidine synthase gene; (2) the presence of single-nucleotide polymorphisms in the methylene tetrahydrofolate reductase gene, and (3) the presence of mRNA splicing in intron 14 of the hepatic enzyme dihydropyrimidine dehydrogenase. The 5-FU gene profile of our patients strongly suggested that the polymorphisms expressed may contribute to the adverse effects seen during the therapy. To what extent these polymorphisms induced adverse effects cannot be established at present; however, our results strengthen the relevance of the 5-FU-related pharmacogenomic profile to predict the response outcome and the chemotherapy toxicity.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalPharmacology
Volume89
Issue number1-2
DOIs
Publication statusPublished - Mar 2012

Keywords

  • 5-Fluorouracil
  • Adverse effects
  • Pharmacogenomics

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Involvement of target gene polymorphisms in 5-fluorouracil toxicity: A case report'. Together they form a unique fingerprint.

Cite this