Involvement of the 4q21 region in human malignant melanomas: Cytogenetic and immunocytochemical characterization of three primary cell cultures

P. Grammatico, M. Roccella, C. Catricalà, F. Roccella, S. Bucher, C. Mordenti, A. Amantea, C. Di Rosa, G. Del Porto

Research output: Contribution to journalArticlepeer-review

Abstract

The GRO1 oncogene (melanoma growth-stimulating activity alpha)_has been localized in region 4q21. The involvement of this chromosomal region in clonal aberrations found in primary melanoma cell cultures could have an important role in the etiology and pathogenesis of this tumor. We characterized three primary cell cultures obtained from different patients, each of which showed clonal chromosomal aberrations involving the 4q21 region.

Original languageEnglish
Pages (from-to)350-351
Number of pages2
JournalWorld Journal of Surgery
Volume19
Issue number3
DOIs
Publication statusPublished - May 1995

ASJC Scopus subject areas

  • Surgery

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