Involvement of the bcl-6 gene in AIDS-related lymphomas

G. Gaidano, C. Pastore, D. Capello, A. Migliazza, A. Gloghini, G. Saglio, A. Carbone, R. Dalla-Favera

Research output: Contribution to journalArticle

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Abstract

Background: Non-Hodgkin's lymphoma (NHL) represents a major complication of AIDS. Systemic AIDS-related NHLs (AIDS-NHLs) derive from B cells and are classified into four distinct groups, including small noncleaved-cell lymphoma (SNCCL), diffuse large-cell lymphoma (DLCL), anaplastic large-cell lymphoma (ALCL), and body-cavity-based lymphoma (BCBL). The molecular pathogenesis of AIDS-NHL is characterized by the association of specific genetic lesions with distinct AIDS-NHL categories. Genetic lesions of AIDS- NHL involve proto-oncogenes (c-myc, Ras), tumor suppressor loci (p53. 6q), and viral infection (Epstein-Barr virus, human herpesvirus type 8). Design: The aim of this work was to define the involvement of the bcl-6 gene in AIDS- related lymphomagenesis by investigating the distribution of bcl-6 structural alterations through out the pathologic spectrum of AIDS-NHL. Both gross rearrangements and mutations in the 5' noncoding regions of the gene were investigated. Results: Gross rearrangements of bcl-6 are confined to a fraction of AIDS-DLCL cases among AIDS-NHLs. Conversely, mutations of the 5' noncoding regions of bcl-6 are detected in a large proportion of AIDS- SNCCLs, AIDS-DLCLs and AIDS-ALCLs independent of the concomitant presence of bcl-6 rearrangements. Conclusions: Mutations of the 5' noncoding regions of bcl-6 represent the most frequent genetic lesion presently detectable among systemic AIDS-NHLs. The frequency of these mutations and their location in the proximity of bcl-6 regulatory regions suggest that they may play a role in AIDS-related lymphoma-genesis.

Original languageEnglish
JournalAnnals of Oncology
Volume8
Issue numberSUPPL. 2
Publication statusPublished - 1997

Fingerprint

AIDS-Related Lymphoma
Acquired Immunodeficiency Syndrome
Genes
Non-Hodgkin's Lymphoma
Lymphoma, Large B-Cell, Diffuse
Mutation
Anaplastic Large-Cell Lymphoma
Human Herpesvirus 8
myc Genes
Nucleic Acid Regulatory Sequences
Virus Diseases
Mutation Rate
Human Herpesvirus 4

Keywords

  • AIDS
  • bcl-6
  • Genetic lesion
  • Lymphoma
  • Oncogene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Gaidano, G., Pastore, C., Capello, D., Migliazza, A., Gloghini, A., Saglio, G., ... Dalla-Favera, R. (1997). Involvement of the bcl-6 gene in AIDS-related lymphomas. Annals of Oncology, 8(SUPPL. 2).

Involvement of the bcl-6 gene in AIDS-related lymphomas. / Gaidano, G.; Pastore, C.; Capello, D.; Migliazza, A.; Gloghini, A.; Saglio, G.; Carbone, A.; Dalla-Favera, R.

In: Annals of Oncology, Vol. 8, No. SUPPL. 2, 1997.

Research output: Contribution to journalArticle

Gaidano, G, Pastore, C, Capello, D, Migliazza, A, Gloghini, A, Saglio, G, Carbone, A & Dalla-Favera, R 1997, 'Involvement of the bcl-6 gene in AIDS-related lymphomas', Annals of Oncology, vol. 8, no. SUPPL. 2.
Gaidano G, Pastore C, Capello D, Migliazza A, Gloghini A, Saglio G et al. Involvement of the bcl-6 gene in AIDS-related lymphomas. Annals of Oncology. 1997;8(SUPPL. 2).
Gaidano, G. ; Pastore, C. ; Capello, D. ; Migliazza, A. ; Gloghini, A. ; Saglio, G. ; Carbone, A. ; Dalla-Favera, R. / Involvement of the bcl-6 gene in AIDS-related lymphomas. In: Annals of Oncology. 1997 ; Vol. 8, No. SUPPL. 2.
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abstract = "Background: Non-Hodgkin's lymphoma (NHL) represents a major complication of AIDS. Systemic AIDS-related NHLs (AIDS-NHLs) derive from B cells and are classified into four distinct groups, including small noncleaved-cell lymphoma (SNCCL), diffuse large-cell lymphoma (DLCL), anaplastic large-cell lymphoma (ALCL), and body-cavity-based lymphoma (BCBL). The molecular pathogenesis of AIDS-NHL is characterized by the association of specific genetic lesions with distinct AIDS-NHL categories. Genetic lesions of AIDS- NHL involve proto-oncogenes (c-myc, Ras), tumor suppressor loci (p53. 6q), and viral infection (Epstein-Barr virus, human herpesvirus type 8). Design: The aim of this work was to define the involvement of the bcl-6 gene in AIDS- related lymphomagenesis by investigating the distribution of bcl-6 structural alterations through out the pathologic spectrum of AIDS-NHL. Both gross rearrangements and mutations in the 5' noncoding regions of the gene were investigated. Results: Gross rearrangements of bcl-6 are confined to a fraction of AIDS-DLCL cases among AIDS-NHLs. Conversely, mutations of the 5' noncoding regions of bcl-6 are detected in a large proportion of AIDS- SNCCLs, AIDS-DLCLs and AIDS-ALCLs independent of the concomitant presence of bcl-6 rearrangements. Conclusions: Mutations of the 5' noncoding regions of bcl-6 represent the most frequent genetic lesion presently detectable among systemic AIDS-NHLs. The frequency of these mutations and their location in the proximity of bcl-6 regulatory regions suggest that they may play a role in AIDS-related lymphoma-genesis.",
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AU - Gaidano, G.

AU - Pastore, C.

AU - Capello, D.

AU - Migliazza, A.

AU - Gloghini, A.

AU - Saglio, G.

AU - Carbone, A.

AU - Dalla-Favera, R.

PY - 1997

Y1 - 1997

N2 - Background: Non-Hodgkin's lymphoma (NHL) represents a major complication of AIDS. Systemic AIDS-related NHLs (AIDS-NHLs) derive from B cells and are classified into four distinct groups, including small noncleaved-cell lymphoma (SNCCL), diffuse large-cell lymphoma (DLCL), anaplastic large-cell lymphoma (ALCL), and body-cavity-based lymphoma (BCBL). The molecular pathogenesis of AIDS-NHL is characterized by the association of specific genetic lesions with distinct AIDS-NHL categories. Genetic lesions of AIDS- NHL involve proto-oncogenes (c-myc, Ras), tumor suppressor loci (p53. 6q), and viral infection (Epstein-Barr virus, human herpesvirus type 8). Design: The aim of this work was to define the involvement of the bcl-6 gene in AIDS- related lymphomagenesis by investigating the distribution of bcl-6 structural alterations through out the pathologic spectrum of AIDS-NHL. Both gross rearrangements and mutations in the 5' noncoding regions of the gene were investigated. Results: Gross rearrangements of bcl-6 are confined to a fraction of AIDS-DLCL cases among AIDS-NHLs. Conversely, mutations of the 5' noncoding regions of bcl-6 are detected in a large proportion of AIDS- SNCCLs, AIDS-DLCLs and AIDS-ALCLs independent of the concomitant presence of bcl-6 rearrangements. Conclusions: Mutations of the 5' noncoding regions of bcl-6 represent the most frequent genetic lesion presently detectable among systemic AIDS-NHLs. The frequency of these mutations and their location in the proximity of bcl-6 regulatory regions suggest that they may play a role in AIDS-related lymphoma-genesis.

AB - Background: Non-Hodgkin's lymphoma (NHL) represents a major complication of AIDS. Systemic AIDS-related NHLs (AIDS-NHLs) derive from B cells and are classified into four distinct groups, including small noncleaved-cell lymphoma (SNCCL), diffuse large-cell lymphoma (DLCL), anaplastic large-cell lymphoma (ALCL), and body-cavity-based lymphoma (BCBL). The molecular pathogenesis of AIDS-NHL is characterized by the association of specific genetic lesions with distinct AIDS-NHL categories. Genetic lesions of AIDS- NHL involve proto-oncogenes (c-myc, Ras), tumor suppressor loci (p53. 6q), and viral infection (Epstein-Barr virus, human herpesvirus type 8). Design: The aim of this work was to define the involvement of the bcl-6 gene in AIDS- related lymphomagenesis by investigating the distribution of bcl-6 structural alterations through out the pathologic spectrum of AIDS-NHL. Both gross rearrangements and mutations in the 5' noncoding regions of the gene were investigated. Results: Gross rearrangements of bcl-6 are confined to a fraction of AIDS-DLCL cases among AIDS-NHLs. Conversely, mutations of the 5' noncoding regions of bcl-6 are detected in a large proportion of AIDS- SNCCLs, AIDS-DLCLs and AIDS-ALCLs independent of the concomitant presence of bcl-6 rearrangements. Conclusions: Mutations of the 5' noncoding regions of bcl-6 represent the most frequent genetic lesion presently detectable among systemic AIDS-NHLs. The frequency of these mutations and their location in the proximity of bcl-6 regulatory regions suggest that they may play a role in AIDS-related lymphoma-genesis.

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KW - bcl-6

KW - Genetic lesion

KW - Lymphoma

KW - Oncogene

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