Involvement of the fak network in pathologies related to altered mechanotransduction

Enrica Urciuoli, Barbara Peruzzi

Research output: Contribution to journalReview articlepeer-review

Abstract

Mechanotransduction is a physiological process in which external mechanical stimulations are perceived, interpreted, and translated by cells into biochemical signals. Mechanical stimulations exerted by extracellular matrix stiffness and cell–cell contacts are continuously applied to living cells, thus representing a key pivotal trigger for cell homeostasis, survival, and function, as well as an essential factor for proper organ development and metabolism. Indeed, a deregulation of the mechanotransduction process consequent to gene mutations or altered functions of proteins involved in perceiving cellular and extracellular mechanics can lead to a broad range of diseases, from muscular dystrophies and cardiomyopathies to cancer development and metastatization. Here, we recapitulate the involvement of focal adhesion kinase (FAK) in the cellular conditions deriving from altered mechanotransduction processes.

Original languageEnglish
Article number9426
Pages (from-to)1-12
Number of pages12
JournalInternational Journal of Molecular Sciences
Volume21
Issue number24
DOIs
Publication statusPublished - Dec 2 2020

Keywords

  • Extracellular matrix
  • Focal Adhesion Kinase (FAK)
  • Focal adhesions
  • Mechanotransduction
  • Tissue matrix stiffness

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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