Involvement of the GABAergic system on shock-induced aggressive behavior in two strains of mice

Stefano Puglisi-Allegra, Simone Simler, Eliane Kempf, Paul Mandel

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of drugs that antagonize or potentiate the action of brain γ-aminobutyric acid (GABA) on shock-induced aggressive behavior in mice were investigated. In previous studies it has been shown that in C57 BL/6 strain shock-induced aggressive behavior is absent up to the 10th week of age and rises to the highest intensity after the 20th week, while at the same ages aggressive responses are lowest or absent in DBA/2 strain. GABA antagonist, picrotoxin and glutamic acid decarboxylase (GAD) inhibitor, D,L-allylglycine induced aggressive responses in non-aggressive 10 week old C57 BL/6 and 20 week old DBA/2 mice. GABA agonist muscimol hydrobromide, and GABA-T inhibitor sodium n-dipropylacetate inhibited aggressive responses in 20 week old C57 BL/6 mice. These effects were not related to changes in shock sensitivity and motor activity. The results strongly suggest that the GABAergic system is involved in the control of shock-induced aggressive behavior in mice and that this control is related to developmental and genetic factors.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume14
Issue numberSUPPL. 1
Publication statusPublished - 1981

Keywords

  • Age
  • Biting
  • D,L-allylglycine
  • Genetic make-up
  • Mice
  • Motor activity
  • Muscimol hydrobromide
  • Picrotoxin
  • Shock sensitivity
  • Shock-induced aggressive behavior
  • Sodium n-dipropyl-acetate

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Pharmacology
  • Toxicology
  • Behavioral Neuroscience
  • Biological Psychiatry

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