Involvement of the short arm of the derivative chromosome 9 in Philadelphia-positive acute lymphoblastic leukemia

Mario Sessarego, Raffaella Defferrari, Giuseppina Fugazza, Adele Comelli, Emanuele Salvidio, Franco Ajmar

Research output: Contribution to journalArticlepeer-review

Abstract

Three Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) patients showed rearrangement of the short arm of the chromosome 9 involved in Ph formation. At diagnosis, blast cells were morphologically L2 and phenotypically B-cell precursors, as shown by common ALL antigen (CALLA), B1, B4 and HLA-DR positivity. Cytogenetically, they had in common the presence of cells with normal karyotypes, the Ph, involvement of band 9p13 p21, and loss of region 9p13 → 9pter. In our experience, involvement of the p arm of the derivative chromosome 9 in Ph+ leukemias is a very rare event found in ALLs only.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume52
Issue number1
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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