TY - JOUR
T1 - Involvement of the short arm of the derivative chromosome 9 in Philadelphia-positive acute lymphoblastic leukemia
AU - Sessarego, Mario
AU - Defferrari, Raffaella
AU - Fugazza, Giuseppina
AU - Comelli, Adele
AU - Salvidio, Emanuele
AU - Ajmar, Franco
PY - 1991
Y1 - 1991
N2 - Three Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) patients showed rearrangement of the short arm of the chromosome 9 involved in Ph formation. At diagnosis, blast cells were morphologically L2 and phenotypically B-cell precursors, as shown by common ALL antigen (CALLA), B1, B4 and HLA-DR positivity. Cytogenetically, they had in common the presence of cells with normal karyotypes, the Ph, involvement of band 9p13 p21, and loss of region 9p13 → 9pter. In our experience, involvement of the p arm of the derivative chromosome 9 in Ph+ leukemias is a very rare event found in ALLs only.
AB - Three Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) patients showed rearrangement of the short arm of the chromosome 9 involved in Ph formation. At diagnosis, blast cells were morphologically L2 and phenotypically B-cell precursors, as shown by common ALL antigen (CALLA), B1, B4 and HLA-DR positivity. Cytogenetically, they had in common the presence of cells with normal karyotypes, the Ph, involvement of band 9p13 p21, and loss of region 9p13 → 9pter. In our experience, involvement of the p arm of the derivative chromosome 9 in Ph+ leukemias is a very rare event found in ALLs only.
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U2 - 10.1016/0165-4608(91)90052-V
DO - 10.1016/0165-4608(91)90052-V
M3 - Article
C2 - 2009511
AN - SCOPUS:0025738323
VL - 52
SP - 43
EP - 49
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -