TY - JOUR
T1 - Involvement of type I immune responses in swine-origin H1N1 influenza virus infection
AU - Frisullo, Giovanni
AU - Iorio, Raffaele
AU - Plantone, Domenico
AU - Nociti, Viviana
AU - Patanella, Agata Katia
AU - Marti, Alessandro
AU - Palermo, Concetta
AU - Valentini, Piero
AU - Mariotti, Paolo
AU - Batocchi, Anna Paola
PY - 2011/8
Y1 - 2011/8
N2 - Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1 with acute necrotizing encephalitis, 2 with pneumonia, and 2 without complications), 5 children with seasonal influenza, and 5 healthy children. We found higher percentages of T-bet + CD4 +CD8 + T cells, monocytes, and B cells, granzyme B + and perforin + CD4 +, and CD8 + T cells in affected children with both seasonal and H1N1 influenza than in controls, whereas both groups demonstrated similar percentages of CD4 +CD25 +Foxp3 + regulatory T cells. In infected children with complications we observed high percentages of perforin + and interferon-γ + CD4 + and CD8 + T cells associated with low percentages of T regulatory cells. Our data suggest a dysregulation of antipathogen type I immune responses in complicated S-OIV infections.
AB - Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1 with acute necrotizing encephalitis, 2 with pneumonia, and 2 without complications), 5 children with seasonal influenza, and 5 healthy children. We found higher percentages of T-bet + CD4 +CD8 + T cells, monocytes, and B cells, granzyme B + and perforin + CD4 +, and CD8 + T cells in affected children with both seasonal and H1N1 influenza than in controls, whereas both groups demonstrated similar percentages of CD4 +CD25 +Foxp3 + regulatory T cells. In infected children with complications we observed high percentages of perforin + and interferon-γ + CD4 + and CD8 + T cells associated with low percentages of T regulatory cells. Our data suggest a dysregulation of antipathogen type I immune responses in complicated S-OIV infections.
KW - Children
KW - Foxp3
KW - Perforin
KW - Swine-origin H1N1 influenza virus
KW - T-bet
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U2 - 10.1016/j.humimm.2011.04.006
DO - 10.1016/j.humimm.2011.04.006
M3 - Article
C2 - 21571020
AN - SCOPUS:79960197448
VL - 72
SP - 632
EP - 635
JO - Human Immunology
JF - Human Immunology
SN - 0198-8859
IS - 8
ER -