Involvement of type I immune responses in swine-origin H1N1 influenza virus infection

Giovanni Frisullo, Raffaele Iorio, Domenico Plantone, Viviana Nociti, Agata Katia Patanella, Alessandro Marti, Concetta Palermo, Piero Valentini, Paolo Mariotti, Anna Paola Batocchi

Research output: Contribution to journalArticlepeer-review


Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1 with acute necrotizing encephalitis, 2 with pneumonia, and 2 without complications), 5 children with seasonal influenza, and 5 healthy children. We found higher percentages of T-bet + CD4 +CD8 + T cells, monocytes, and B cells, granzyme B + and perforin + CD4 +, and CD8 + T cells in affected children with both seasonal and H1N1 influenza than in controls, whereas both groups demonstrated similar percentages of CD4 +CD25 +Foxp3 + regulatory T cells. In infected children with complications we observed high percentages of perforin + and interferon-γ + CD4 + and CD8 + T cells associated with low percentages of T regulatory cells. Our data suggest a dysregulation of antipathogen type I immune responses in complicated S-OIV infections.

Original languageEnglish
Pages (from-to)632-635
Number of pages4
JournalHuman Immunology
Issue number8
Publication statusPublished - Aug 2011


  • Children
  • Foxp3
  • Perforin
  • Swine-origin H1N1 influenza virus
  • T-bet

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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