TY - JOUR
T1 - Iodine-123 metaiodobenzylguanidine scintigraphy and iodine-123 ioflupane single photon emission computed tomography in lewy body diseases
T2 - Complementary or alternative techniques?
AU - Treglia, Giorgio
AU - Cason, Ernesto
AU - Cortelli, Pietro
AU - Gabellini, Anna
AU - Liguori, Rocco
AU - Bagnato, Antonio
AU - Giordano, Alessandro
AU - Fagioli, Giorgio
PY - 2014/3
Y1 - 2014/3
N2 - PURPOSE: To compare myocardial sympathetic imaging using 123I-Metaiodobenzylguanidine (MIBG) scintigraphy and striatal dopaminergic imaging using 123I-Ioflupane (FP-CIT) single photon emission computed tomography (SPECT) in patients with suspected Lewy body diseases (LBD). METHODS: Ninety-nine patients who performed both methods within 2 months for differential diagnosis between Parkinson's disease (PD) and other parkinsonism (n = 68) or between dementia with Lewy bodies (DLB) and other dementia (n = 31) were enrolled. Sensitivity, specificity, accuracy, positive and negative predictive values of both methods were calculated. RESULTS: For 123I-MIBG scintigraphy, the overall sensitivity, specificity, accuracy, positive and negative predictive values in LBD were 83%, 79%, 82%, 86%, and 76%, respectively. For 123I-FP-CIT SPECT, the overall sensitivity, specificity, accuracy, positive and negative predictive values in LBD were 93%, 41%, 73%, 71%, and 80%, respectively. There was a statistically significant difference between these two methods in patients without LBD, but not in patients with LBD. CONCLUSIONS: LBD usually present both myocardial sympathetic and striatal dopaminergic impairments. 123I-FP-CIT SPECT presents high sensitivity in the diagnosis of LBD; 123I-MIBG scintigraphy may have a complementary role in differential diagnosis between PD and other parkinsonism. These scintigraphic methods showed similar diagnostic accuracy in differential diagnosis between DLB and other dementia.
AB - PURPOSE: To compare myocardial sympathetic imaging using 123I-Metaiodobenzylguanidine (MIBG) scintigraphy and striatal dopaminergic imaging using 123I-Ioflupane (FP-CIT) single photon emission computed tomography (SPECT) in patients with suspected Lewy body diseases (LBD). METHODS: Ninety-nine patients who performed both methods within 2 months for differential diagnosis between Parkinson's disease (PD) and other parkinsonism (n = 68) or between dementia with Lewy bodies (DLB) and other dementia (n = 31) were enrolled. Sensitivity, specificity, accuracy, positive and negative predictive values of both methods were calculated. RESULTS: For 123I-MIBG scintigraphy, the overall sensitivity, specificity, accuracy, positive and negative predictive values in LBD were 83%, 79%, 82%, 86%, and 76%, respectively. For 123I-FP-CIT SPECT, the overall sensitivity, specificity, accuracy, positive and negative predictive values in LBD were 93%, 41%, 73%, 71%, and 80%, respectively. There was a statistically significant difference between these two methods in patients without LBD, but not in patients with LBD. CONCLUSIONS: LBD usually present both myocardial sympathetic and striatal dopaminergic impairments. 123I-FP-CIT SPECT presents high sensitivity in the diagnosis of LBD; 123I-MIBG scintigraphy may have a complementary role in differential diagnosis between PD and other parkinsonism. These scintigraphic methods showed similar diagnostic accuracy in differential diagnosis between DLB and other dementia.
KW - Dementia with Lewy bodies
KW - Ioflupane
KW - Lewy body disease
KW - Metaiodobenzylguanidine
KW - Nuclear medicine
KW - Parkinson's disease
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U2 - 10.1111/j.1552-6569.2012.00774.x
DO - 10.1111/j.1552-6569.2012.00774.x
M3 - Article
C2 - 23163913
AN - SCOPUS:84896699978
VL - 24
SP - 149
EP - 154
JO - Journal of Neuroimaging
JF - Journal of Neuroimaging
SN - 1051-2284
IS - 2
ER -