TY - JOUR
T1 - Iodothyronine deiodinases and reduced sensitivity to thyroid hormones
AU - Paragliola, Rosa Maria
AU - Corsello, Andrea
AU - Concolino, Paola
AU - Ianni, Francesca
AU - Papi, Giampaolo
AU - Pontecorvi, Alfredo
AU - Corsello, Salvatore Maria
N1 - Publisher Copyright:
© 2020 Frontiers in Bioscience. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Iodothyronine deiodinases are selenoproteins that regulate thyroid hormone metabolism. Of the three types of deiodinases, type 2 is the major regulator of intracellular triiodothyronine concentration in both the hypothalamus and pituitary, and therefore the major regulator of thyrotropin secretion. A defect in iodothyronine deiodinase activity can lead to a reduced sensitivity to thyroid hormones action and the most recent literature includes these defects in the so-called “syndromes of reduced sensitivity to thyroid hormones”. To date, the pathogenic variants of the selenocysteine insertion sequence-binding protein 2 (SECISBP2) gene are the first and only inherited disorder of iodothyronine metabolism described. Moreover, there is a growing interest in understanding the possible role of polymorphisms of DIO1 and DIO2 genes in some pathological conditions and in determining the requirement of levothyroxine replacement and the role of combined levothyroxine-liothyronine therapy in carrying subjects affected by hypothyroidism and who need replacement therapy. Results on this topic are still conflicting and more studies are needed to assess the efficacy of combined levothyroxine-liothyronine replacement therapy in this subset of patients.
AB - Iodothyronine deiodinases are selenoproteins that regulate thyroid hormone metabolism. Of the three types of deiodinases, type 2 is the major regulator of intracellular triiodothyronine concentration in both the hypothalamus and pituitary, and therefore the major regulator of thyrotropin secretion. A defect in iodothyronine deiodinase activity can lead to a reduced sensitivity to thyroid hormones action and the most recent literature includes these defects in the so-called “syndromes of reduced sensitivity to thyroid hormones”. To date, the pathogenic variants of the selenocysteine insertion sequence-binding protein 2 (SECISBP2) gene are the first and only inherited disorder of iodothyronine metabolism described. Moreover, there is a growing interest in understanding the possible role of polymorphisms of DIO1 and DIO2 genes in some pathological conditions and in determining the requirement of levothyroxine replacement and the role of combined levothyroxine-liothyronine therapy in carrying subjects affected by hypothyroidism and who need replacement therapy. Results on this topic are still conflicting and more studies are needed to assess the efficacy of combined levothyroxine-liothyronine replacement therapy in this subset of patients.
KW - DIO Polymorphism
KW - Hypothalamus–Pituitary–Thyroid Axis
KW - Iodothyronine Deiodinases
KW - Reduced Sensitivity To Thyroid Hormone
KW - Review
KW - SECISBP2
KW - Thyroid Hormone
UR - http://www.scopus.com/inward/record.url?scp=85072936189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072936189&partnerID=8YFLogxK
U2 - 10.2741/4803
DO - 10.2741/4803
M3 - Review article
C2 - 31585886
AN - SCOPUS:85072936189
VL - 25
SP - 201
EP - 228
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
SN - 1093-9946
IS - 2
ER -