Iodothyronine deiodinases and reduced sensitivity to thyroid hormones

Rosa Maria Paragliola, Andrea Corsello, Paola Concolino, Francesca Ianni, Giampaolo Papi, Alfredo Pontecorvi, Salvatore Maria Corsello

Research output: Contribution to journalReview articlepeer-review


Iodothyronine deiodinases are selenoproteins that regulate thyroid hormone metabolism. Of the three types of deiodinases, type 2 is the major regulator of intracellular triiodothyronine concentration in both the hypothalamus and pituitary, and therefore the major regulator of thyrotropin secretion. A defect in iodothyronine deiodinase activity can lead to a reduced sensitivity to thyroid hormones action and the most recent literature includes these defects in the so-called “syndromes of reduced sensitivity to thyroid hormones”. To date, the pathogenic variants of the selenocysteine insertion sequence-binding protein 2 (SECISBP2) gene are the first and only inherited disorder of iodothyronine metabolism described. Moreover, there is a growing interest in understanding the possible role of polymorphisms of DIO1 and DIO2 genes in some pathological conditions and in determining the requirement of levothyroxine replacement and the role of combined levothyroxine-liothyronine therapy in carrying subjects affected by hypothyroidism and who need replacement therapy. Results on this topic are still conflicting and more studies are needed to assess the efficacy of combined levothyroxine-liothyronine replacement therapy in this subset of patients.

Original languageEnglish
Pages (from-to)201-228
Number of pages28
JournalFrontiers in Bioscience - Landmark
Issue number2
Publication statusPublished - Jan 1 2020


  • DIO Polymorphism
  • Hypothalamus–Pituitary–Thyroid Axis
  • Iodothyronine Deiodinases
  • Reduced Sensitivity To Thyroid Hormone
  • Review
  • Thyroid Hormone

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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