Ionic homeostasis in brain conditioning

Ornella Cuomo, Antonio Vinciguerra, Pierpaolo Cerullo, Serenella Anzilotti, Paola Brancaccio, Leonilda Bilo, Antonella Scorziello, Pasquale Molinaro, Gianfranco Di Renzo, Giuseppe Pignataro

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Most of the research aimed at identifying new stroke therapies focuses on strategies which induce, mimic, or boost endogenous protective responses. Preconditioning is a protective strategy in which a subliminal stimulus is applied before a subsequent harmful stimulus, thus inducing a state of tolerance in which the injury inflicted by the challenge is mitigated. Tolerance may be observed in ischemia, seizure, and infection. Since it requires protein synthesis, it confers delayed and temporary neuroprotection, taking hours to develop, with a pick at 1-3 days. A new promising approach for neuroprotection derives from postconditioning, in which neuroprotection is achieved by a modified reperfusion subsequent to a prolonged ischemic episode. Many pathways have been proposed as plausible mechanisms to explain the neuroprotection offered by preconditioning and postconditioning. Although the mechanisms are not yet fully understood, recent evidence highlights the preminent role of the ionic homeostasis maintenance. The present article will review the role of ionic transporters and channels involved in the control of ionic homeostasis in the neuroprotective effect of ischemic preconditioning and postconditioning in adult brain, with particular regards to Na+/Ca2+ exchangers (NCXs), plasma membrane Ca2+-ATPase (PMCA), Na+/H+ exchanger (NHE), Na+/K+/2Cl- cotransport (NKCC) and acid-sensing ionic channels (ASIC).

Original languageEnglish
Article number277
JournalFrontiers in Neuroscience
Volume9
Issue numberJUL
DOIs
Publication statusPublished - 2015

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Homeostasis
Brain
Ion Channels
Ischemic Postconditioning
Ischemic Preconditioning
Sodium-Hydrogen Antiporter
Calcium-Transporting ATPases
Neuroprotective Agents
Reperfusion
Seizures
Ischemia
Stroke
Maintenance
Cell Membrane
Acids
Neuroprotection
Wounds and Injuries
Infection
Research
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cuomo, O., Vinciguerra, A., Cerullo, P., Anzilotti, S., Brancaccio, P., Bilo, L., ... Pignataro, G. (2015). Ionic homeostasis in brain conditioning. Frontiers in Neuroscience, 9(JUL), [277]. https://doi.org/10.3389/fnins.2015.00277

Ionic homeostasis in brain conditioning. / Cuomo, Ornella; Vinciguerra, Antonio; Cerullo, Pierpaolo; Anzilotti, Serenella; Brancaccio, Paola; Bilo, Leonilda; Scorziello, Antonella; Molinaro, Pasquale; Di Renzo, Gianfranco; Pignataro, Giuseppe.

In: Frontiers in Neuroscience, Vol. 9, No. JUL, 277, 2015.

Research output: Contribution to journalArticle

Cuomo, O, Vinciguerra, A, Cerullo, P, Anzilotti, S, Brancaccio, P, Bilo, L, Scorziello, A, Molinaro, P, Di Renzo, G & Pignataro, G 2015, 'Ionic homeostasis in brain conditioning', Frontiers in Neuroscience, vol. 9, no. JUL, 277. https://doi.org/10.3389/fnins.2015.00277
Cuomo O, Vinciguerra A, Cerullo P, Anzilotti S, Brancaccio P, Bilo L et al. Ionic homeostasis in brain conditioning. Frontiers in Neuroscience. 2015;9(JUL). 277. https://doi.org/10.3389/fnins.2015.00277
Cuomo, Ornella ; Vinciguerra, Antonio ; Cerullo, Pierpaolo ; Anzilotti, Serenella ; Brancaccio, Paola ; Bilo, Leonilda ; Scorziello, Antonella ; Molinaro, Pasquale ; Di Renzo, Gianfranco ; Pignataro, Giuseppe. / Ionic homeostasis in brain conditioning. In: Frontiers in Neuroscience. 2015 ; Vol. 9, No. JUL.
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