Ionic selectivity of volume-sensitivity currents in human epithalial cells

Andrea Rasola, Luis J V Galieta, Dieter C. Gruenert, Giovanni Romeo

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The ion selectivity of welling-activated Cl- currents has been investigated in three different human epithelial cell lines, two derived from the airway epithelium (9HTEo- and CFNPE9o-) and one form from a colon carcinoma (T84). The relative permeability of volume-sensitive currents with respect to Cl- is: I-(1.19) > NO3 - (1.07) ≈ Br-(1.05) > Cl- (1.0) > F-(0.5) ≈ HCO3 -(0.48) > isethionate(0.28) > aspartate (0.14) ≈ gluconate(0.13)≈SO4 2- (0.12). This type of ion selectivity is similar to that described for depolarization-activated outwarding rectifying Cl- channels found in epithelial cells.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Issue number4
Publication statusPublished - Aug 25 1992

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology
  • Molecular Medicine


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