IP-10 is an additional marker for tuberculosis (TB) detection in HIV-infected persons in a low-TB endemic country

Valentina Vanini, Elisa Petruccioli, Cristiana Gioia, Gilda Cuzzi, Nicoletta Orchi, Alessia Rianda, Lucia Alba, Maria Letizia Giancola, Aristide Conte, Vincenzo Schininà, Elisa Busi Rizzi, Enrico Girardi, Delia Goletti

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: In Indian HIV-infected patients, IP-10 response to QuantiFERON-TB Gold In tube (QFT-IT) antigens has been associated to tuberculosis (TB). However, specificity for active TB was lower than that reported by QFT-IT, making accuracy for TB detection questionable. To investigate this uncertainty, likely due to India being highly endemic for TB, and to better identify TB correlates, we evaluated the IP-10-based assay in HIV-infected subjects in Italy, a low-TB endemic country. Methods: 195 individuals were prospectively enrolled; 118 were HIV-infected (21 with active TB, 97 without active TB, and distinguished as high/low-TB-risk). QFT-IT was performed and IP-10 was evaluated by ELISA. Results: Among the HIV-infected individuals, sensitivity for active TB was 66.7% by IP-10-based test and 52.4% (p = 1) by QFT-IT. IP-10-based assay showed a lower dependence on mitogen-response and CD4 counts than QFT-IT. Among subjects without active TB, a higher proportion of IP-10 responders was shown in high-TB-risk subjects than low-TB-risk subjects (40.0% vs 12.9%), similar to QFT-IT (37.1% vs 4.8%). Low-TB risk subjects showed 87.1% specificity for active TB by IP-10-based test vs 95.2% by QFT-IT. Conclusions: In a low-TB endemic country, besides IFN-γ, IP-10 response to QFT-IT is associated with active TB and TB risk factors in HIV-infected patients with lower dependence on mitogen-response and CD4 counts.

Original languageEnglish
Pages (from-to)49-59
Number of pages11
JournalJournal of Infection
Volume65
Issue number1
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Diagnosis
  • HIV
  • IGRA
  • Immune deficiency
  • IP-10
  • Low TB endemic country
  • QuantiFERON
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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