Ipsilateral breast tumor reappearance in patients treated with conservative surgery after primary chemotherapy. The role of surgical margins on outcome

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Abstract

Background and Objectives: To evaluate the ipsilateral breast tumor reappearance (IBTR) rate after breast conservative surgery (BCS) following primary chemotherapy (PC) and to assess whether positive margins affects IBTR rate and overall survival (OS). Methods: Three hundred nine women candidates for mastectomy received PC before surgery. One hundred ninety-five patients (63.1%) underwent BCS and 114 patients (36.9%) a modified radical mastectomy. Results: After a median follow-up of 41 months (range 7-90), 13 patients of the 195 treated with BCS had an IBTR (6.7%), 6 patients had a regional relapse (3.1%), 28 women had distant metastases (14.4%). Twenty-three patients died of breast cancer (11.8%). Twenty-four patients treated with BCS had positive margins (12.3%). At 3 years, the crude cumulative incidence of local recurrence was 4.7% in women with negative margins, and 13.3% in women with positive margins (P = 0.05). Cumulative incidence of distant metastases was similar in patients with positive and negative margins (P = 0.16) and there was no significant difference in terms of OS according to the margin status (P = 0.577). Conclusions: BCS after PC has an acceptable rate of IBTR. After a short follow-up, the presence of positive margins does not affect OS.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalJournal of Surgical Oncology
Volume94
Issue number5
DOIs
Publication statusPublished - Oct 1 2006

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Breast Neoplasms
Drug Therapy
Breast
Neoplasm Metastasis
Modified Radical Mastectomy
Recurrence
Survival
Mastectomy
Incidence
Margins of Excision
Survival Rate

Keywords

  • Breast conservation
  • Local relapse
  • Primary chemotherapy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

@article{068900b56b84422281ddeb00ad0b2572,
title = "Ipsilateral breast tumor reappearance in patients treated with conservative surgery after primary chemotherapy. The role of surgical margins on outcome",
abstract = "Background and Objectives: To evaluate the ipsilateral breast tumor reappearance (IBTR) rate after breast conservative surgery (BCS) following primary chemotherapy (PC) and to assess whether positive margins affects IBTR rate and overall survival (OS). Methods: Three hundred nine women candidates for mastectomy received PC before surgery. One hundred ninety-five patients (63.1{\%}) underwent BCS and 114 patients (36.9{\%}) a modified radical mastectomy. Results: After a median follow-up of 41 months (range 7-90), 13 patients of the 195 treated with BCS had an IBTR (6.7{\%}), 6 patients had a regional relapse (3.1{\%}), 28 women had distant metastases (14.4{\%}). Twenty-three patients died of breast cancer (11.8{\%}). Twenty-four patients treated with BCS had positive margins (12.3{\%}). At 3 years, the crude cumulative incidence of local recurrence was 4.7{\%} in women with negative margins, and 13.3{\%} in women with positive margins (P = 0.05). Cumulative incidence of distant metastases was similar in patients with positive and negative margins (P = 0.16) and there was no significant difference in terms of OS according to the margin status (P = 0.577). Conclusions: BCS after PC has an acceptable rate of IBTR. After a short follow-up, the presence of positive margins does not affect OS.",
keywords = "Breast conservation, Local relapse, Primary chemotherapy",
author = "Oreste Gentilini and Mattia Intra and Sara Gandini and Giulia Peruzzotti and Erik Winnikow and Alberto Luini and Paolo Veronesi and Viviana Galimberti and Aron Goldhirsch and Umberto Veronesi",
year = "2006",
month = "10",
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language = "English",
volume = "94",
pages = "375--379",
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TY - JOUR

T1 - Ipsilateral breast tumor reappearance in patients treated with conservative surgery after primary chemotherapy. The role of surgical margins on outcome

AU - Gentilini, Oreste

AU - Intra, Mattia

AU - Gandini, Sara

AU - Peruzzotti, Giulia

AU - Winnikow, Erik

AU - Luini, Alberto

AU - Veronesi, Paolo

AU - Galimberti, Viviana

AU - Goldhirsch, Aron

AU - Veronesi, Umberto

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Background and Objectives: To evaluate the ipsilateral breast tumor reappearance (IBTR) rate after breast conservative surgery (BCS) following primary chemotherapy (PC) and to assess whether positive margins affects IBTR rate and overall survival (OS). Methods: Three hundred nine women candidates for mastectomy received PC before surgery. One hundred ninety-five patients (63.1%) underwent BCS and 114 patients (36.9%) a modified radical mastectomy. Results: After a median follow-up of 41 months (range 7-90), 13 patients of the 195 treated with BCS had an IBTR (6.7%), 6 patients had a regional relapse (3.1%), 28 women had distant metastases (14.4%). Twenty-three patients died of breast cancer (11.8%). Twenty-four patients treated with BCS had positive margins (12.3%). At 3 years, the crude cumulative incidence of local recurrence was 4.7% in women with negative margins, and 13.3% in women with positive margins (P = 0.05). Cumulative incidence of distant metastases was similar in patients with positive and negative margins (P = 0.16) and there was no significant difference in terms of OS according to the margin status (P = 0.577). Conclusions: BCS after PC has an acceptable rate of IBTR. After a short follow-up, the presence of positive margins does not affect OS.

AB - Background and Objectives: To evaluate the ipsilateral breast tumor reappearance (IBTR) rate after breast conservative surgery (BCS) following primary chemotherapy (PC) and to assess whether positive margins affects IBTR rate and overall survival (OS). Methods: Three hundred nine women candidates for mastectomy received PC before surgery. One hundred ninety-five patients (63.1%) underwent BCS and 114 patients (36.9%) a modified radical mastectomy. Results: After a median follow-up of 41 months (range 7-90), 13 patients of the 195 treated with BCS had an IBTR (6.7%), 6 patients had a regional relapse (3.1%), 28 women had distant metastases (14.4%). Twenty-three patients died of breast cancer (11.8%). Twenty-four patients treated with BCS had positive margins (12.3%). At 3 years, the crude cumulative incidence of local recurrence was 4.7% in women with negative margins, and 13.3% in women with positive margins (P = 0.05). Cumulative incidence of distant metastases was similar in patients with positive and negative margins (P = 0.16) and there was no significant difference in terms of OS according to the margin status (P = 0.577). Conclusions: BCS after PC has an acceptable rate of IBTR. After a short follow-up, the presence of positive margins does not affect OS.

KW - Breast conservation

KW - Local relapse

KW - Primary chemotherapy

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