Irinotecan in combination with new agents

U. Vanhoefer, P. Rougier, M. Borner, A. Muñoz, J. L. Van Laethem, A. Sobrero

Research output: Contribution to journalArticle

Abstract

Today, irinotecan in combination with bolus and/or infusional 5-FU/FA constitutes a standard first-line treatment for patients with metastatic colorectal cancer. In an attempt to further improve clinical outcome, the use of irinotecan in combination with novel, targeted agents has been investigated. The theoretical attraction of combining irinotecan with targeted therapies is that this can improve the efficacy of treatment, but, due to the mainly non-overlapping toxicities of the agents involved, the toxicity of treatment should not be exacerbated. In this article we discuss recent data from clinical studies looking at the combinations of irinotecan with the 5-fluorouracil (5-FU) pro-drug, capecitabine, the cyclo-oxygenase (COX-2) inhibitor, celecoxib, and monoclonal antibodies against the epidermal growth factor receptor (cetuximab) and vascular endothelial growth factor (bevacizumab).

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalEuropean Journal of Cancer, Supplement
Volume2
Issue number7
DOIs
Publication statusPublished - Jun 2004

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Keywords

  • Bevacizumab
  • Capecitabine
  • Celecoxib
  • Cetuximab
  • Colorectal cancer
  • Irinotecan

ASJC Scopus subject areas

  • Cancer Research

Cite this

Vanhoefer, U., Rougier, P., Borner, M., Muñoz, A., Van Laethem, J. L., & Sobrero, A. (2004). Irinotecan in combination with new agents. European Journal of Cancer, Supplement, 2(7), 14-20. https://doi.org/10.1016/j.ejcsup.2004.04.010