Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

Andrea Palermo, Rocky Strollo, Ernesto Maddaloni, Dario Tuccinardi, Luca D'Onofrio, Silvia Irina Briganti, Giuseppe Defeudis, Mariangela De Pascalis, Maria Concetta Lazzaro, Georgia Colleluori, Silvia Manfrini, Paolo Pozzilli, Nicola Napoli

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Abstract

Background Although there is an evidence of correlation between irisin and osteoporotic fractures, previous studies have not elucidated the relationship between irisin and either lean or fat mass. The main aim of this study is to investigate the relationship between irisin and body composition in postmenopausal women with osteoporosis and the impact of irisin levels on fragility vertebral fractures. Methods In this cross-sectional study, 36 overweight subjects affected by at least one vertebral osteoporotic fracture confirmed by an X-ray vertebral morphometry and 36 overweight nonosteoporotic subjects were enrolled. Serum irisin levels were measured using an irisin competitive ELISA. We evaluated lumbar spine and hip BMD and body composition using dual energy X-ray absorptiometry. To measure and monitor daily physical activity, each subject wore an armband for approximately 72 h. Results No significant correlations were found between irisin and BMD at any site and between irisin with either lean or fat mass. Serum levels of irisin were not correlated with the daily physical activity. Serum irisin levels were lower in subjects with previous osteoporotic fractures than in controls (P = 0·032), and the difference in irisin levels remained significant after adjustment for creatinine (P = 0·037), vitamin D (P = 0·046), lean mass (P = 0·02), lumbar BMD (P = 0·023) and femoral BMD (P = 0·032). Conclusion Our data confirm an inverse correlation between irisin levels and vertebral fragility fractures, but no significant correlation was found with BMD or lean mass. Irisin may play a protective role on bone health independent of BMD but further studies are needed to clarify the relationship between irisin and bone metabolism.

Original languageEnglish
Pages (from-to)615-619
Number of pages5
JournalClinical Endocrinology
Volume82
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

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Osteoporotic Fractures
Body Composition
Bone Density
Exercise
Serum
Fats
Bone and Bones
Photon Absorptiometry
Thigh
Vitamin D
Osteoporosis
Hip
Creatinine
Spine
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
X-Rays
Health

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Palermo, A., Strollo, R., Maddaloni, E., Tuccinardi, D., D'Onofrio, L., Briganti, S. I., ... Napoli, N. (2015). Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity. Clinical Endocrinology, 82(4), 615-619. https://doi.org/10.1111/cen.12672

Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity. / Palermo, Andrea; Strollo, Rocky; Maddaloni, Ernesto; Tuccinardi, Dario; D'Onofrio, Luca; Briganti, Silvia Irina; Defeudis, Giuseppe; De Pascalis, Mariangela; Lazzaro, Maria Concetta; Colleluori, Georgia; Manfrini, Silvia; Pozzilli, Paolo; Napoli, Nicola.

In: Clinical Endocrinology, Vol. 82, No. 4, 01.04.2015, p. 615-619.

Research output: Contribution to journalArticle

Palermo, A, Strollo, R, Maddaloni, E, Tuccinardi, D, D'Onofrio, L, Briganti, SI, Defeudis, G, De Pascalis, M, Lazzaro, MC, Colleluori, G, Manfrini, S, Pozzilli, P & Napoli, N 2015, 'Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity', Clinical Endocrinology, vol. 82, no. 4, pp. 615-619. https://doi.org/10.1111/cen.12672
Palermo, Andrea ; Strollo, Rocky ; Maddaloni, Ernesto ; Tuccinardi, Dario ; D'Onofrio, Luca ; Briganti, Silvia Irina ; Defeudis, Giuseppe ; De Pascalis, Mariangela ; Lazzaro, Maria Concetta ; Colleluori, Georgia ; Manfrini, Silvia ; Pozzilli, Paolo ; Napoli, Nicola. / Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity. In: Clinical Endocrinology. 2015 ; Vol. 82, No. 4. pp. 615-619.
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abstract = "Background Although there is an evidence of correlation between irisin and osteoporotic fractures, previous studies have not elucidated the relationship between irisin and either lean or fat mass. The main aim of this study is to investigate the relationship between irisin and body composition in postmenopausal women with osteoporosis and the impact of irisin levels on fragility vertebral fractures. Methods In this cross-sectional study, 36 overweight subjects affected by at least one vertebral osteoporotic fracture confirmed by an X-ray vertebral morphometry and 36 overweight nonosteoporotic subjects were enrolled. Serum irisin levels were measured using an irisin competitive ELISA. We evaluated lumbar spine and hip BMD and body composition using dual energy X-ray absorptiometry. To measure and monitor daily physical activity, each subject wore an armband for approximately 72 h. Results No significant correlations were found between irisin and BMD at any site and between irisin with either lean or fat mass. Serum levels of irisin were not correlated with the daily physical activity. Serum irisin levels were lower in subjects with previous osteoporotic fractures than in controls (P = 0·032), and the difference in irisin levels remained significant after adjustment for creatinine (P = 0·037), vitamin D (P = 0·046), lean mass (P = 0·02), lumbar BMD (P = 0·023) and femoral BMD (P = 0·032). Conclusion Our data confirm an inverse correlation between irisin levels and vertebral fragility fractures, but no significant correlation was found with BMD or lean mass. Irisin may play a protective role on bone health independent of BMD but further studies are needed to clarify the relationship between irisin and bone metabolism.",
author = "Andrea Palermo and Rocky Strollo and Ernesto Maddaloni and Dario Tuccinardi and Luca D'Onofrio and Briganti, {Silvia Irina} and Giuseppe Defeudis and {De Pascalis}, Mariangela and Lazzaro, {Maria Concetta} and Georgia Colleluori and Silvia Manfrini and Paolo Pozzilli and Nicola Napoli",
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T1 - Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

AU - Palermo, Andrea

AU - Strollo, Rocky

AU - Maddaloni, Ernesto

AU - Tuccinardi, Dario

AU - D'Onofrio, Luca

AU - Briganti, Silvia Irina

AU - Defeudis, Giuseppe

AU - De Pascalis, Mariangela

AU - Lazzaro, Maria Concetta

AU - Colleluori, Georgia

AU - Manfrini, Silvia

AU - Pozzilli, Paolo

AU - Napoli, Nicola

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background Although there is an evidence of correlation between irisin and osteoporotic fractures, previous studies have not elucidated the relationship between irisin and either lean or fat mass. The main aim of this study is to investigate the relationship between irisin and body composition in postmenopausal women with osteoporosis and the impact of irisin levels on fragility vertebral fractures. Methods In this cross-sectional study, 36 overweight subjects affected by at least one vertebral osteoporotic fracture confirmed by an X-ray vertebral morphometry and 36 overweight nonosteoporotic subjects were enrolled. Serum irisin levels were measured using an irisin competitive ELISA. We evaluated lumbar spine and hip BMD and body composition using dual energy X-ray absorptiometry. To measure and monitor daily physical activity, each subject wore an armband for approximately 72 h. Results No significant correlations were found between irisin and BMD at any site and between irisin with either lean or fat mass. Serum levels of irisin were not correlated with the daily physical activity. Serum irisin levels were lower in subjects with previous osteoporotic fractures than in controls (P = 0·032), and the difference in irisin levels remained significant after adjustment for creatinine (P = 0·037), vitamin D (P = 0·046), lean mass (P = 0·02), lumbar BMD (P = 0·023) and femoral BMD (P = 0·032). Conclusion Our data confirm an inverse correlation between irisin levels and vertebral fragility fractures, but no significant correlation was found with BMD or lean mass. Irisin may play a protective role on bone health independent of BMD but further studies are needed to clarify the relationship between irisin and bone metabolism.

AB - Background Although there is an evidence of correlation between irisin and osteoporotic fractures, previous studies have not elucidated the relationship between irisin and either lean or fat mass. The main aim of this study is to investigate the relationship between irisin and body composition in postmenopausal women with osteoporosis and the impact of irisin levels on fragility vertebral fractures. Methods In this cross-sectional study, 36 overweight subjects affected by at least one vertebral osteoporotic fracture confirmed by an X-ray vertebral morphometry and 36 overweight nonosteoporotic subjects were enrolled. Serum irisin levels were measured using an irisin competitive ELISA. We evaluated lumbar spine and hip BMD and body composition using dual energy X-ray absorptiometry. To measure and monitor daily physical activity, each subject wore an armband for approximately 72 h. Results No significant correlations were found between irisin and BMD at any site and between irisin with either lean or fat mass. Serum levels of irisin were not correlated with the daily physical activity. Serum irisin levels were lower in subjects with previous osteoporotic fractures than in controls (P = 0·032), and the difference in irisin levels remained significant after adjustment for creatinine (P = 0·037), vitamin D (P = 0·046), lean mass (P = 0·02), lumbar BMD (P = 0·023) and femoral BMD (P = 0·032). Conclusion Our data confirm an inverse correlation between irisin levels and vertebral fragility fractures, but no significant correlation was found with BMD or lean mass. Irisin may play a protective role on bone health independent of BMD but further studies are needed to clarify the relationship between irisin and bone metabolism.

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DO - 10.1111/cen.12672

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VL - 82

SP - 615

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JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

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