Abstract
Background Although there is an evidence of correlation between irisin and osteoporotic fractures, previous studies have not elucidated the relationship between irisin and either lean or fat mass. The main aim of this study is to investigate the relationship between irisin and body composition in postmenopausal women with osteoporosis and the impact of irisin levels on fragility vertebral fractures. Methods In this cross-sectional study, 36 overweight subjects affected by at least one vertebral osteoporotic fracture confirmed by an X-ray vertebral morphometry and 36 overweight nonosteoporotic subjects were enrolled. Serum irisin levels were measured using an irisin competitive ELISA. We evaluated lumbar spine and hip BMD and body composition using dual energy X-ray absorptiometry. To measure and monitor daily physical activity, each subject wore an armband for approximately 72 h. Results No significant correlations were found between irisin and BMD at any site and between irisin with either lean or fat mass. Serum levels of irisin were not correlated with the daily physical activity. Serum irisin levels were lower in subjects with previous osteoporotic fractures than in controls (P = 0·032), and the difference in irisin levels remained significant after adjustment for creatinine (P = 0·037), vitamin D (P = 0·046), lean mass (P = 0·02), lumbar BMD (P = 0·023) and femoral BMD (P = 0·032). Conclusion Our data confirm an inverse correlation between irisin levels and vertebral fragility fractures, but no significant correlation was found with BMD or lean mass. Irisin may play a protective role on bone health independent of BMD but further studies are needed to clarify the relationship between irisin and bone metabolism.
| Original language | English |
|---|---|
| Pages (from-to) | 615-619 |
| Number of pages | 5 |
| Journal | Clinical Endocrinology |
| Volume | 82 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2015 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Medicine(all)
Cite this
Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity. / Palermo, Andrea; Strollo, Rocky; Maddaloni, Ernesto; Tuccinardi, Dario; D'Onofrio, Luca; Briganti, Silvia Irina; Defeudis, Giuseppe; De Pascalis, Mariangela; Lazzaro, Maria Concetta; Colleluori, Georgia; Manfrini, Silvia; Pozzilli, Paolo; Napoli, Nicola.
In: Clinical Endocrinology, Vol. 82, No. 4, 01.04.2015, p. 615-619.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity
AU - Palermo, Andrea
AU - Strollo, Rocky
AU - Maddaloni, Ernesto
AU - Tuccinardi, Dario
AU - D'Onofrio, Luca
AU - Briganti, Silvia Irina
AU - Defeudis, Giuseppe
AU - De Pascalis, Mariangela
AU - Lazzaro, Maria Concetta
AU - Colleluori, Georgia
AU - Manfrini, Silvia
AU - Pozzilli, Paolo
AU - Napoli, Nicola
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Background Although there is an evidence of correlation between irisin and osteoporotic fractures, previous studies have not elucidated the relationship between irisin and either lean or fat mass. The main aim of this study is to investigate the relationship between irisin and body composition in postmenopausal women with osteoporosis and the impact of irisin levels on fragility vertebral fractures. Methods In this cross-sectional study, 36 overweight subjects affected by at least one vertebral osteoporotic fracture confirmed by an X-ray vertebral morphometry and 36 overweight nonosteoporotic subjects were enrolled. Serum irisin levels were measured using an irisin competitive ELISA. We evaluated lumbar spine and hip BMD and body composition using dual energy X-ray absorptiometry. To measure and monitor daily physical activity, each subject wore an armband for approximately 72 h. Results No significant correlations were found between irisin and BMD at any site and between irisin with either lean or fat mass. Serum levels of irisin were not correlated with the daily physical activity. Serum irisin levels were lower in subjects with previous osteoporotic fractures than in controls (P = 0·032), and the difference in irisin levels remained significant after adjustment for creatinine (P = 0·037), vitamin D (P = 0·046), lean mass (P = 0·02), lumbar BMD (P = 0·023) and femoral BMD (P = 0·032). Conclusion Our data confirm an inverse correlation between irisin levels and vertebral fragility fractures, but no significant correlation was found with BMD or lean mass. Irisin may play a protective role on bone health independent of BMD but further studies are needed to clarify the relationship between irisin and bone metabolism.
AB - Background Although there is an evidence of correlation between irisin and osteoporotic fractures, previous studies have not elucidated the relationship between irisin and either lean or fat mass. The main aim of this study is to investigate the relationship between irisin and body composition in postmenopausal women with osteoporosis and the impact of irisin levels on fragility vertebral fractures. Methods In this cross-sectional study, 36 overweight subjects affected by at least one vertebral osteoporotic fracture confirmed by an X-ray vertebral morphometry and 36 overweight nonosteoporotic subjects were enrolled. Serum irisin levels were measured using an irisin competitive ELISA. We evaluated lumbar spine and hip BMD and body composition using dual energy X-ray absorptiometry. To measure and monitor daily physical activity, each subject wore an armband for approximately 72 h. Results No significant correlations were found between irisin and BMD at any site and between irisin with either lean or fat mass. Serum levels of irisin were not correlated with the daily physical activity. Serum irisin levels were lower in subjects with previous osteoporotic fractures than in controls (P = 0·032), and the difference in irisin levels remained significant after adjustment for creatinine (P = 0·037), vitamin D (P = 0·046), lean mass (P = 0·02), lumbar BMD (P = 0·023) and femoral BMD (P = 0·032). Conclusion Our data confirm an inverse correlation between irisin levels and vertebral fragility fractures, but no significant correlation was found with BMD or lean mass. Irisin may play a protective role on bone health independent of BMD but further studies are needed to clarify the relationship between irisin and bone metabolism.
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U2 - 10.1111/cen.12672
DO - 10.1111/cen.12672
M3 - Article
VL - 82
SP - 615
EP - 619
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 4
ER -