Irisin Serum Levels in Metabolic Syndrome Patients Treated with Three Different Diets: A Post-Hoc Analysis from a Randomized Controlled Clinical Trial

Alberto R Osella, Graziana Colaianni, Mario Correale, Pasqua L Pesole, Irene Bruno, Claudia Buongiorno, Valentina Deflorio, Carla M Leone, Silvia Concetta Colucci, Maria Grano, Gianluigi Giannelli

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Irisin, a hormone-like myokine, regulates energy homeostasis and mediates the benefits of physical activity on health.

METHODS: To estimate the effect of different diets on irisin concentrations in subjects with the Metabolic Syndrome (MetS).

METHODS: Subjects with MetS were derived from a population survey; 163 subjects were enrolled and randomized to a: Low Glycaemic Index (LGID), Mediterranean (MD) or Low Glycaemic Index Mediterranean (LGIMD) Diet, and the groups were compared, also with 80 controls without MetS. Sociodemographic, medical and nutritional data were collected and fasting blood samples drawn. Subjects underwent LUS and bioimpedentiometry. Generalized Estimating Equations were performed.

RESULTS: At baseline, lower irisin concentrations were observed in MetS subjects. Mean irisin levels increased in all diet groups but only the LGID group reached statistical significance, as well as showing an interaction between LGID and time at the sixth month examination (4.57, 95% CI −1.27, 7.87). There was a positive effect of Vegetable Proteins (0.03, 95% CI −0.01,0.06) and Saturated Fatty Acids (0.04, 95% CI 0.01, 0.07) on irisin concentrations. In the LGIMD, a positive effect on Fat-Free Mass (0.38, 95% CI 0.19, 0.57) and a negative effect on the Body Mass Index (−0.75, 95% CI −1.30, −0.19) were observed.

CONCLUSIONS: There seems to be a link between diet and muscle physiology. We showed that patients following a LGID had higher levels of irisin, a promising biomarker of muscle activity.

Original languageEnglish
Pages (from-to)844
Number of pages14
JournalNutrients
Volume10
Issue number7
DOIs
Publication statusPublished - Jun 28 2018

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers/blood
  • Diet, Mediterranean
  • Fatty Acids/administration & dosage
  • Female
  • Fibronectins/blood
  • Glycemic Index
  • Humans
  • Italy
  • Male
  • Metabolic Syndrome/blood
  • Middle Aged
  • Muscle, Skeletal/metabolism
  • Patient Compliance
  • Plant Proteins, Dietary/administration & dosage
  • Time Factors
  • Treatment Outcome

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