Iron and erythropoiesis: A dual relationship

Clara Camaschella, Alessia Pagani

Research output: Contribution to journalArticlepeer-review

Abstract

Iron is essential for cell life and especially for erythropoiesis which is the major body consumer of iron for red cell production. The study of genetic disorders of iron metabolism, the identification of iron transporters and of the role of hepcidin as the key regulator of systemic iron homeostasis have greatly contributed to our understanding of iron handling by the erythroid marrow. Spontaneous and engineered animal models of iron disorders have help to add further insights to the issue. A still incompletely understood aspect remains the regulation that erythropoiesis exerts on iron.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalInternational Journal of Hematology
Volume93
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Erythropoiesis
  • Hepcidin
  • Iron

ASJC Scopus subject areas

  • Hematology

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