Iron burden and liver fibrosis decrease during a long-term phlebotomy program and iron chelating treatment after bone marrow transplantation

Anna Meo, Annalisa Ruggeri, Maria A. La Rosa, Laura Zanghì, Nancy Morabito, Lorena Duca

Research output: Contribution to journalArticlepeer-review

Abstract

In this retrospective study, we report the results of the association of a combined phlebotomy program and chelation in hereditary sideroblastic anemia (HSA) to reduce iron overload after bone marrow transplantation (BMT). A male HSA patient, not responding to pyridoxine treatment, was submitted to successful allogeneic BMT. As there was a persistence of a tissue iron overload, a regular phlebotomy program was started followed by chelation. A significant decrease of iron burden was obtained using a combined treatment with deferoxamine (DFO) and deferiprone (L1) in addition to the phlebotomy program. A 10-year follow-up shows a marked decrease in the concentration of serum ferritin, non-transferrin-bound iron (NTBI), liver iron and normal hemoglobin (Hb), which allows the patient to reach and maintain a good quality of life.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalHemoglobin
Volume30
Issue number1
DOIs
Publication statusPublished - Feb 2006

Keywords

  • Bone marrow transplantation (BMT)
  • Deferiprone (L1)
  • Deferoxamine (DFO)
  • Hereditary sideroblastic anemia (HSA)
  • Iron overload
  • Phlebotomy

ASJC Scopus subject areas

  • Hematology
  • Biochemistry

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