TY - JOUR
T1 - Iron burden and liver fibrosis decrease during a long-term phlebotomy program and iron chelating treatment after bone marrow transplantation
AU - Meo, Anna
AU - Ruggeri, Annalisa
AU - La Rosa, Maria A.
AU - Zanghì, Laura
AU - Morabito, Nancy
AU - Duca, Lorena
PY - 2006/2
Y1 - 2006/2
N2 - In this retrospective study, we report the results of the association of a combined phlebotomy program and chelation in hereditary sideroblastic anemia (HSA) to reduce iron overload after bone marrow transplantation (BMT). A male HSA patient, not responding to pyridoxine treatment, was submitted to successful allogeneic BMT. As there was a persistence of a tissue iron overload, a regular phlebotomy program was started followed by chelation. A significant decrease of iron burden was obtained using a combined treatment with deferoxamine (DFO) and deferiprone (L1) in addition to the phlebotomy program. A 10-year follow-up shows a marked decrease in the concentration of serum ferritin, non-transferrin-bound iron (NTBI), liver iron and normal hemoglobin (Hb), which allows the patient to reach and maintain a good quality of life.
AB - In this retrospective study, we report the results of the association of a combined phlebotomy program and chelation in hereditary sideroblastic anemia (HSA) to reduce iron overload after bone marrow transplantation (BMT). A male HSA patient, not responding to pyridoxine treatment, was submitted to successful allogeneic BMT. As there was a persistence of a tissue iron overload, a regular phlebotomy program was started followed by chelation. A significant decrease of iron burden was obtained using a combined treatment with deferoxamine (DFO) and deferiprone (L1) in addition to the phlebotomy program. A 10-year follow-up shows a marked decrease in the concentration of serum ferritin, non-transferrin-bound iron (NTBI), liver iron and normal hemoglobin (Hb), which allows the patient to reach and maintain a good quality of life.
KW - Bone marrow transplantation (BMT)
KW - Deferiprone (L1)
KW - Deferoxamine (DFO)
KW - Hereditary sideroblastic anemia (HSA)
KW - Iron overload
KW - Phlebotomy
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U2 - 10.1080/03630260500455615
DO - 10.1080/03630260500455615
M3 - Article
C2 - 16540426
AN - SCOPUS:33645062663
VL - 30
SP - 131
EP - 137
JO - Hemoglobin
JF - Hemoglobin
SN - 0363-0269
IS - 1
ER -