Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis

Jesper Hagemeier, E. Ann Yeh, Mari Heininen Brown, Niels Bergsland, Michael G. Dwyer, Ellen Carl, Bianca Weinstock-Guttman, Robert Zivadinov

Research output: Contribution to journalArticle

Abstract

Objective: The objective of this paper is to assess abnormal phase values, indicative of increased iron content, using susceptibility-weighted imaging (SWI)-filtered phase of the subcortical deep gray matter (SDGM) in adolescent multiple sclerosis (MS) and other neurological disorders (OND) patients, and in healthy controls (HC). Methods: Twenty adolescent MS and eight adolescent OND patients and 21 age- and sex-matched HC were scanned on a 3T GE scanner. Mean phase of abnormal phase tissue (MP-APT), MP-APT volume, normal phase tissue volume (NPTV) and normalized volume measurements were obtained for total SDGM, as well as specific structures separately. Results: Significantly increased MP-APT (28.2%, p

Original languageEnglish
Pages (from-to)567-576
Number of pages10
JournalMultiple Sclerosis Journal
Volume19
Issue number5
DOIs
Publication statusPublished - 2013

Keywords

  • abnormal phase
  • Adolescent multiple sclerosis
  • atrophy
  • inflammation
  • iron deposition
  • pediatric
  • phase images
  • susceptibility-weighted imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Hagemeier, J., Yeh, E. A., Brown, M. H., Bergsland, N., Dwyer, M. G., Carl, E., Weinstock-Guttman, B., & Zivadinov, R. (2013). Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis. Multiple Sclerosis Journal, 19(5), 567-576. https://doi.org/10.1177/1352458512459289