Iron deficiency: An ominous sign in patients with systolic chronic heart failure

Ewa A. Jankowska; Piotr Rozentryt; Agnieszka Witkowska; Jolanta Nowak; Oliver Hartmann; Beata Ponikowska; Ludmila Borodulin-Nadzieja; Waldemar Banasiak; Lech Polonski; Gerasimos Filippatos; John J V McMurray; Stefan D. Anker; Piotr Ponikowski

doi:10.1093/eurheartj/ehq158

Iron deficiency: An ominous sign in patients with systolic chronic heart failure

Ewa A. Jankowska, Piotr Rozentryt, Agnieszka Witkowska, Jolanta Nowak, Oliver Hartmann, Beata Ponikowska, Ludmila Borodulin-Nadzieja, Waldemar Banasiak, Lech Polonski, Gerasimos Filippatos, John J V McMurray, Stefan D. Anker, Piotr Ponikowski

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Aims Beyond erythropoiesis, iron is involved in numerous biological processes crucial for maintenance of homeostasis. Patients with chronic heart failure (CHF) are prone to develop iron deficiency (ID), and iron supplementation improves their functional status and quality of life. We sought to examine the relationship between ID and survival in patients with systolic CHF. Methods and resultsIn a prospective observational study, we evaluated 546 patients with stable systolic CHF [age: 55 ± 11 (mean ± standard deviation) years, males: 88, left ventricular ejection fraction: 26 ± 7, New York Heart Association (NYHA) class (I/II/III/IV): 57/221/226/42]. Iron deficiency was defined as: ferritin

Original language	English
Pages (from-to)	1872-1880
Number of pages	9
Journal	European Heart Journal
Volume	31
Issue number	15
DOIs	https://doi.org/10.1093/eurheartj/ehq158
Publication status	Published - Aug 2010

Keywords

Chronic heart failure
Iron deficiency
Survival

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1093/eurheartj/ehq158

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Jankowska, E. A., Rozentryt, P., Witkowska, A., Nowak, J., Hartmann, O., Ponikowska, B., Borodulin-Nadzieja, L., Banasiak, W., Polonski, L., Filippatos, G., McMurray, J. J. V., Anker, S. D., & Ponikowski, P. (2010). Iron deficiency: An ominous sign in patients with systolic chronic heart failure. European Heart Journal, 31(15), 1872-1880. https://doi.org/10.1093/eurheartj/ehq158

Iron deficiency : An ominous sign in patients with systolic chronic heart failure. / Jankowska, Ewa A.; Rozentryt, Piotr; Witkowska, Agnieszka; Nowak, Jolanta; Hartmann, Oliver; Ponikowska, Beata; Borodulin-Nadzieja, Ludmila; Banasiak, Waldemar; Polonski, Lech; Filippatos, Gerasimos; McMurray, John J V; Anker, Stefan D.; Ponikowski, Piotr.

In: European Heart Journal, Vol. 31, No. 15, 08.2010, p. 1872-1880.

Research output: Contribution to journal › Article › peer-review

Jankowska, EA, Rozentryt, P, Witkowska, A, Nowak, J, Hartmann, O, Ponikowska, B, Borodulin-Nadzieja, L, Banasiak, W, Polonski, L, Filippatos, G, McMurray, JJV, Anker, SD & Ponikowski, P 2010, 'Iron deficiency: An ominous sign in patients with systolic chronic heart failure', European Heart Journal, vol. 31, no. 15, pp. 1872-1880. https://doi.org/10.1093/eurheartj/ehq158

Jankowska, Ewa A. ; Rozentryt, Piotr ; Witkowska, Agnieszka ; Nowak, Jolanta ; Hartmann, Oliver ; Ponikowska, Beata ; Borodulin-Nadzieja, Ludmila ; Banasiak, Waldemar ; Polonski, Lech ; Filippatos, Gerasimos ; McMurray, John J V ; Anker, Stefan D. ; Ponikowski, Piotr. / Iron deficiency : An ominous sign in patients with systolic chronic heart failure. In: European Heart Journal. 2010 ; Vol. 31, No. 15. pp. 1872-1880.

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abstract = "Aims Beyond erythropoiesis, iron is involved in numerous biological processes crucial for maintenance of homeostasis. Patients with chronic heart failure (CHF) are prone to develop iron deficiency (ID), and iron supplementation improves their functional status and quality of life. We sought to examine the relationship between ID and survival in patients with systolic CHF. Methods and resultsIn a prospective observational study, we evaluated 546 patients with stable systolic CHF [age: 55 ± 11 (mean ± standard deviation) years, males: 88, left ventricular ejection fraction: 26 ± 7, New York Heart Association (NYHA) class (I/II/III/IV): 57/221/226/42]. Iron deficiency was defined as: ferritin ",

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AU - Nowak, Jolanta

AU - Hartmann, Oliver

AU - Ponikowska, Beata

AU - Borodulin-Nadzieja, Ludmila

AU - Banasiak, Waldemar

AU - Polonski, Lech

AU - Filippatos, Gerasimos

AU - McMurray, John J V

AU - Anker, Stefan D.

AU - Ponikowski, Piotr

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AB - Aims Beyond erythropoiesis, iron is involved in numerous biological processes crucial for maintenance of homeostasis. Patients with chronic heart failure (CHF) are prone to develop iron deficiency (ID), and iron supplementation improves their functional status and quality of life. We sought to examine the relationship between ID and survival in patients with systolic CHF. Methods and resultsIn a prospective observational study, we evaluated 546 patients with stable systolic CHF [age: 55 ± 11 (mean ± standard deviation) years, males: 88, left ventricular ejection fraction: 26 ± 7, New York Heart Association (NYHA) class (I/II/III/IV): 57/221/226/42]. Iron deficiency was defined as: ferritin

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