Iron deficiency: An ominous sign in patients with systolic chronic heart failure

Ewa A. Jankowska, Piotr Rozentryt, Agnieszka Witkowska, Jolanta Nowak, Oliver Hartmann, Beata Ponikowska, Ludmila Borodulin-Nadzieja, Waldemar Banasiak, Lech Polonski, Gerasimos Filippatos, John J V McMurray, Stefan D. Anker, Piotr Ponikowski

Research output: Contribution to journalArticlepeer-review


Aims Beyond erythropoiesis, iron is involved in numerous biological processes crucial for maintenance of homeostasis. Patients with chronic heart failure (CHF) are prone to develop iron deficiency (ID), and iron supplementation improves their functional status and quality of life. We sought to examine the relationship between ID and survival in patients with systolic CHF. Methods and resultsIn a prospective observational study, we evaluated 546 patients with stable systolic CHF [age: 55 ± 11 (mean ± standard deviation) years, males: 88, left ventricular ejection fraction: 26 ± 7, New York Heart Association (NYHA) class (I/II/III/IV): 57/221/226/42]. Iron deficiency was defined as: ferritin

Original languageEnglish
Pages (from-to)1872-1880
Number of pages9
JournalEuropean Heart Journal
Issue number15
Publication statusPublished - Aug 2010


  • Chronic heart failure
  • Iron deficiency
  • Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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