Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure

Ewa A. Jankowska; Monika Kasztura; Mateusz Sokolski; Marek Bronisz; Sylwia Nawrocka; Weronika Oleśkowska-Florek; Robert Zymliński; Jan Biegus; Paweł Siwołowski; Waldemar Banasiak; Stefan D. Anker; Gerasimos Filippatos; John G F Cleland; Piotr Ponikowski

doi:10.1093/eurheartj/ehu235

Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure

Ewa A. Jankowska, Monika Kasztura, Mateusz Sokolski, Marek Bronisz, Sylwia Nawrocka, Weronika Oleśkowska-Florek, Robert Zymliński, Jan Biegus, Paweł Siwołowski, Waldemar Banasiak, Stefan D. Anker, Gerasimos Filippatos, John G F Cleland, Piotr Ponikowski

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: Acute heart failure (AHF) critically deranges haemodynamic and metabolic homoeostasis. Iron is a key micronutrient for homoeostasis maintenance. We hypothesized that iron deficiency (ID) defined as depleted iron stores accompanied by unmet cellular iron requirements would in this setting predict the poor outcome.

METHODS AND RESULTS: Among 165 AHF patients (age 65 ± 12 years, 81% men, 31% de novo HF), for ID diagnosis we prospectively applied: low serum hepcidin reflecting depleted iron stores (

CONCLUSION: Iron deficiency defined as depleted body iron stores and unmet cellular iron requirements is common in AHF, and identifies those with the poor outcome. Its correction may be an attractive therapeutic approach.

Original language	English
Pages (from-to)	2468-2476
Number of pages	9
Journal	European Heart Journal
Volume	35
Issue number	36
DOIs	https://doi.org/10.1093/eurheartj/ehu235
Publication status	Published - Sep 21 2014

Keywords

Acute heart failure
Hepcidin
Iron status
Mortality
Soluble transferrin receptor

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1093/eurheartj/ehu235

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Jankowska, E. A., Kasztura, M., Sokolski, M., Bronisz, M., Nawrocka, S., Oleśkowska-Florek, W., Zymliński, R., Biegus, J., Siwołowski, P., Banasiak, W., Anker, S. D., Filippatos, G., Cleland, J. G. F., & Ponikowski, P. (2014). Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure. European Heart Journal, 35(36), 2468-2476. https://doi.org/10.1093/eurheartj/ehu235

Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure. / Jankowska, Ewa A.; Kasztura, Monika; Sokolski, Mateusz; Bronisz, Marek; Nawrocka, Sylwia; Oleśkowska-Florek, Weronika; Zymliński, Robert; Biegus, Jan; Siwołowski, Paweł; Banasiak, Waldemar; Anker, Stefan D.; Filippatos, Gerasimos; Cleland, John G F; Ponikowski, Piotr.

In: European Heart Journal, Vol. 35, No. 36, 21.09.2014, p. 2468-2476.

Research output: Contribution to journal › Article › peer-review

Jankowska, EA, Kasztura, M, Sokolski, M, Bronisz, M, Nawrocka, S, Oleśkowska-Florek, W, Zymliński, R, Biegus, J, Siwołowski, P, Banasiak, W, Anker, SD, Filippatos, G, Cleland, JGF & Ponikowski, P 2014, 'Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure', European Heart Journal, vol. 35, no. 36, pp. 2468-2476. https://doi.org/10.1093/eurheartj/ehu235

Jankowska, Ewa A. ; Kasztura, Monika ; Sokolski, Mateusz ; Bronisz, Marek ; Nawrocka, Sylwia ; Oleśkowska-Florek, Weronika ; Zymliński, Robert ; Biegus, Jan ; Siwołowski, Paweł ; Banasiak, Waldemar ; Anker, Stefan D. ; Filippatos, Gerasimos ; Cleland, John G F ; Ponikowski, Piotr. / Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure. In: European Heart Journal. 2014 ; Vol. 35, No. 36. pp. 2468-2476.

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abstract = "AIM: Acute heart failure (AHF) critically deranges haemodynamic and metabolic homoeostasis. Iron is a key micronutrient for homoeostasis maintenance. We hypothesized that iron deficiency (ID) defined as depleted iron stores accompanied by unmet cellular iron requirements would in this setting predict the poor outcome.METHODS AND RESULTS: Among 165 AHF patients (age 65 ± 12 years, 81% men, 31% de novo HF), for ID diagnosis we prospectively applied: low serum hepcidin reflecting depleted iron stores (CONCLUSION: Iron deficiency defined as depleted body iron stores and unmet cellular iron requirements is common in AHF, and identifies those with the poor outcome. Its correction may be an attractive therapeutic approach.",

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AU - Jankowska, Ewa A.

AU - Kasztura, Monika

AU - Sokolski, Mateusz

AU - Bronisz, Marek

AU - Nawrocka, Sylwia

AU - Oleśkowska-Florek, Weronika

AU - Zymliński, Robert

AU - Biegus, Jan

AU - Siwołowski, Paweł

AU - Banasiak, Waldemar

AU - Anker, Stefan D.

AU - Filippatos, Gerasimos

AU - Cleland, John G F

AU - Ponikowski, Piotr

PY - 2014/9/21

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AB - AIM: Acute heart failure (AHF) critically deranges haemodynamic and metabolic homoeostasis. Iron is a key micronutrient for homoeostasis maintenance. We hypothesized that iron deficiency (ID) defined as depleted iron stores accompanied by unmet cellular iron requirements would in this setting predict the poor outcome.METHODS AND RESULTS: Among 165 AHF patients (age 65 ± 12 years, 81% men, 31% de novo HF), for ID diagnosis we prospectively applied: low serum hepcidin reflecting depleted iron stores (CONCLUSION: Iron deficiency defined as depleted body iron stores and unmet cellular iron requirements is common in AHF, and identifies those with the poor outcome. Its correction may be an attractive therapeutic approach.

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KW - Soluble transferrin receptor

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