Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure

Ewa A. Jankowska, Monika Kasztura, Mateusz Sokolski, Marek Bronisz, Sylwia Nawrocka, Weronika Oleśkowska-Florek, Robert Zymliński, Jan Biegus, Paweł Siwołowski, Waldemar Banasiak, Stefan D. Anker, Gerasimos Filippatos, John G F Cleland, Piotr Ponikowski

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: Acute heart failure (AHF) critically deranges haemodynamic and metabolic homoeostasis. Iron is a key micronutrient for homoeostasis maintenance. We hypothesized that iron deficiency (ID) defined as depleted iron stores accompanied by unmet cellular iron requirements would in this setting predict the poor outcome.

METHODS AND RESULTS: Among 165 AHF patients (age 65 ± 12 years, 81% men, 31% de novo HF), for ID diagnosis we prospectively applied: low serum hepcidin reflecting depleted iron stores (

CONCLUSION: Iron deficiency defined as depleted body iron stores and unmet cellular iron requirements is common in AHF, and identifies those with the poor outcome. Its correction may be an attractive therapeutic approach.

Original languageEnglish
Pages (from-to)2468-2476
Number of pages9
JournalEuropean Heart Journal
Volume35
Issue number36
DOIs
Publication statusPublished - Sep 21 2014

Keywords

  • Acute heart failure
  • Hepcidin
  • Iron status
  • Mortality
  • Soluble transferrin receptor

ASJC Scopus subject areas

  • Medicine(all)

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