TY - JOUR
T1 - Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure
AU - Jankowska, Ewa A.
AU - Kasztura, Monika
AU - Sokolski, Mateusz
AU - Bronisz, Marek
AU - Nawrocka, Sylwia
AU - Oleśkowska-Florek, Weronika
AU - Zymliński, Robert
AU - Biegus, Jan
AU - Siwołowski, Paweł
AU - Banasiak, Waldemar
AU - Anker, Stefan D.
AU - Filippatos, Gerasimos
AU - Cleland, John G F
AU - Ponikowski, Piotr
PY - 2014/9/21
Y1 - 2014/9/21
N2 - AIM: Acute heart failure (AHF) critically deranges haemodynamic and metabolic homoeostasis. Iron is a key micronutrient for homoeostasis maintenance. We hypothesized that iron deficiency (ID) defined as depleted iron stores accompanied by unmet cellular iron requirements would in this setting predict the poor outcome.METHODS AND RESULTS: Among 165 AHF patients (age 65 ± 12 years, 81% men, 31% de novo HF), for ID diagnosis we prospectively applied: low serum hepcidin reflecting depleted iron stores (CONCLUSION: Iron deficiency defined as depleted body iron stores and unmet cellular iron requirements is common in AHF, and identifies those with the poor outcome. Its correction may be an attractive therapeutic approach.
AB - AIM: Acute heart failure (AHF) critically deranges haemodynamic and metabolic homoeostasis. Iron is a key micronutrient for homoeostasis maintenance. We hypothesized that iron deficiency (ID) defined as depleted iron stores accompanied by unmet cellular iron requirements would in this setting predict the poor outcome.METHODS AND RESULTS: Among 165 AHF patients (age 65 ± 12 years, 81% men, 31% de novo HF), for ID diagnosis we prospectively applied: low serum hepcidin reflecting depleted iron stores (CONCLUSION: Iron deficiency defined as depleted body iron stores and unmet cellular iron requirements is common in AHF, and identifies those with the poor outcome. Its correction may be an attractive therapeutic approach.
KW - Acute heart failure
KW - Hepcidin
KW - Iron status
KW - Mortality
KW - Soluble transferrin receptor
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U2 - 10.1093/eurheartj/ehu235
DO - 10.1093/eurheartj/ehu235
M3 - Article
C2 - 24927731
AN - SCOPUS:84923680702
VL - 35
SP - 2468
EP - 2476
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 36
ER -