TY - JOUR
T1 - Iron deficiency predicts impaired exercise capacity in patients with systolic chronic heart failure
AU - Jankowska, Ewa A.
AU - Rozentryt, Piotr
AU - Witkowska, Agnieszka
AU - Nowak, Jolanta
AU - Hartmann, Oliver
AU - Ponikowska, Beata
AU - Borodulin-Nadzieja, Ludmila
AU - Von Haehling, Stephan
AU - Doehner, Wolfram
AU - Banasiak, Waldemar
AU - Polonski, Lech
AU - Filippatos, Gerasimos
AU - Anker, Stefan D.
AU - Ponikowski, Piotr
PY - 2011/11
Y1 - 2011/11
N2 - Background: Iron is an indispensable element of hemoglobin, myoglobin, and cytochromes, and, beyond erythropoiesis, is involved in oxidative metabolism and cellular energetics. Hence, iron deficiency (ID) is anticipated to limit exercise capacity. We investigated whether ID predicted exercise intolerance in patients with systolic chronic heart failure (CHF). Methods and Results: We prospectively studied 443 patients with stable systolic CHF (age 54 ± 10 years, males 90%, ejection fraction 26 ± 7%, New York Heart Association Class I/II/III/IV 49/188/180/26). ID was defined as: serum ferritin 2) and ventilatory response to exercise (VE-VCO 2 slope). ID was present in 35 ± 4% (±95% confidence interval) of patients with systolic CHF. Those with ID had reduced peak VO 2 and increased VE-VCO 2 slope as compared to subjects without ID (peak VO 2: 13.3 ± 4.0 versus 15.3 ± 4.5 mL•min•kg, VE-VCO 2 slope: 50.9 ± 15.8 versus 43.1 ± 11.1, respectively, both P 2 (β = -0.14, P 2 slope (β = 0.14, P 2 and VE-VCO 2 slope (P
AB - Background: Iron is an indispensable element of hemoglobin, myoglobin, and cytochromes, and, beyond erythropoiesis, is involved in oxidative metabolism and cellular energetics. Hence, iron deficiency (ID) is anticipated to limit exercise capacity. We investigated whether ID predicted exercise intolerance in patients with systolic chronic heart failure (CHF). Methods and Results: We prospectively studied 443 patients with stable systolic CHF (age 54 ± 10 years, males 90%, ejection fraction 26 ± 7%, New York Heart Association Class I/II/III/IV 49/188/180/26). ID was defined as: serum ferritin 2) and ventilatory response to exercise (VE-VCO 2 slope). ID was present in 35 ± 4% (±95% confidence interval) of patients with systolic CHF. Those with ID had reduced peak VO 2 and increased VE-VCO 2 slope as compared to subjects without ID (peak VO 2: 13.3 ± 4.0 versus 15.3 ± 4.5 mL•min•kg, VE-VCO 2 slope: 50.9 ± 15.8 versus 43.1 ± 11.1, respectively, both P 2 (β = -0.14, P 2 slope (β = 0.14, P 2 and VE-VCO 2 slope (P
KW - anemia
KW - Chronic heart failure
KW - exercise intolerance
KW - iron deficiency
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U2 - 10.1016/j.cardfail.2011.08.003
DO - 10.1016/j.cardfail.2011.08.003
M3 - Article
C2 - 22041326
AN - SCOPUS:80155190205
VL - 17
SP - 899
EP - 906
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
SN - 1071-9164
IS - 11
ER -