Abstract
Iron deposition in the brain normally increase with age, but its accumulation in certain regions is observed in a number of neurodegenerative diseases including Parkinson’s disease (PD) and other parkinsonisms. Whether iron overload leads to dopaminergic neuronal death in the SN of PD patients or is instead simply a by-product of the neurodegenerative progression is still yet to be ascertained. Magnetic resonance imaging (MRI) is a non-invasive method to assess brain iron content in PD patients. In PD, accurate radiologic visualization of basal ganglia is required. Deep gray matter nuclei are well presented in T2- and T2*-weighted images. T2*-weighted gradient-echo (GRE) is widely used to assess calcifications and also for iron detection. On the other hand, new methods specifically designed for detecting iron-induced susceptibility differences can be further improved by sequences like susceptibility-weighted imaging (SWI). In the present review, we aim to summarize the available data on brain iron deposition in PD.
Original language | English |
---|---|
Pages (from-to) | 2095-2101 |
Number of pages | 7 |
Journal | Neurological Sciences |
Volume | 38 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 1 2017 |
Keywords
- Iron
- Magnetic resonance imaging
- Parkinsonian disorders
- Parkinson’s disease
ASJC Scopus subject areas
- Dermatology
- Clinical Neurology
- Psychiatry and Mental health