Iron overload in subjects with beta-thalassaemia trait: Role of idiopathic haemochromatosis gene

S. Fargion, A. Piperno, N. Panaiotopoulos, M. T. Taddei, G. Fiorelli

Research output: Contribution to journalArticlepeer-review

Abstract

We have characterized HLA antigens in subjects with beta-thalassaemia trait with and without iron overload. 50% of the cases with iron overload (ν 18% of those without iron overload, P <0.01) are carriers of HLA-A3, the HLA antigen tightly linked to the IH allele. Thus, in a considerable number of these subjects, beta-thalassaemia and IH coexist. This association exerts a synergistic effect in inducing iron overload.

Original languageEnglish
Pages (from-to)487-490
Number of pages4
JournalBritish Journal of Haematology
Volume61
Issue number3
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Hematology

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