Iron-related indexes in chronic alcoholics. Effect of alcohol withdrawal

D. Conte, M. Corsetti, A. Colli, M. T. Bardella, M. Cocciolo, A. Maestroni, M. Fraquelli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background. Increased serum transferrin saturation and ferritin levels have been reported in chronic alcoholics. Aim. To evaluate modifications in serum iron-related indexes in chronic alcohol abusers with and without cirrhosis, at enrolment and after complete alcohol withdrawal. Patients. Fifty-one consecutive chronic alcohol abusers, 33 without and 18 with cirrhosis. Methods. Liver function tests were performed and transferrin saturation percent and serum ferritin levels measured at time 0 and after 7 and 14 days of complete alcohol withdrawal. Results. Duration of alcohol abuse was significantly longer in patients with cirrhosis than in those without (24 ± 13 SD vs 18 ± 13 SD years, p <0.01). A concomitant increase in transferrin saturation percent and serum ferritin was found in 60% of the cirrhotics and 45% of the non cirrhotic group. During the observation period transferrin saturation percent and serum ferritin fell significantly in both groups (from 59 ± 33 SD to 36 ± 22% SD, p <0.05, and from 900 ± 933 SD to 469 ± 457 SD ng/ml, p <0.01, in cirrhotics, and from 46 ± 30 SD to 27 ± 12% SD, p <0.01, and from 702 ± 602 SD to 340 ± 290 SD ng/ml, p <0.01, in non cirrhotics). Conclusions. Iron-related indexes increase with chronic alcohol abuse and return to normal rapidly after complete alcohol withdrawal. In chronic alcoholics the timing of determinations of iron-related indexes is crucial, and screening for possible concomitant genetic haemochromatosis must be postponed.

Original languageEnglish
Pages (from-to)534-538
Number of pages5
JournalItalian Journal of Gastroenterology and Hepatology
Volume30
Issue number5
Publication statusPublished - 1998

Fingerprint

Alcoholics
Transferrin
Ferritins
Iron
Alcohols
Serum
Fibrosis
Alcoholism
Hemochromatosis
Liver Function Tests
Observation

Keywords

  • Alcohol abuse
  • Alcohol withdrawal
  • Cirrhosis
  • Ferritin
  • Haemochromatosis
  • Hepatitis B virus
  • Hepatitis C virus
  • Transferrin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Conte, D., Corsetti, M., Colli, A., Bardella, M. T., Cocciolo, M., Maestroni, A., & Fraquelli, M. (1998). Iron-related indexes in chronic alcoholics. Effect of alcohol withdrawal. Italian Journal of Gastroenterology and Hepatology, 30(5), 534-538.

Iron-related indexes in chronic alcoholics. Effect of alcohol withdrawal. / Conte, D.; Corsetti, M.; Colli, A.; Bardella, M. T.; Cocciolo, M.; Maestroni, A.; Fraquelli, M.

In: Italian Journal of Gastroenterology and Hepatology, Vol. 30, No. 5, 1998, p. 534-538.

Research output: Contribution to journalArticle

Conte, D, Corsetti, M, Colli, A, Bardella, MT, Cocciolo, M, Maestroni, A & Fraquelli, M 1998, 'Iron-related indexes in chronic alcoholics. Effect of alcohol withdrawal', Italian Journal of Gastroenterology and Hepatology, vol. 30, no. 5, pp. 534-538.
Conte D, Corsetti M, Colli A, Bardella MT, Cocciolo M, Maestroni A et al. Iron-related indexes in chronic alcoholics. Effect of alcohol withdrawal. Italian Journal of Gastroenterology and Hepatology. 1998;30(5):534-538.
Conte, D. ; Corsetti, M. ; Colli, A. ; Bardella, M. T. ; Cocciolo, M. ; Maestroni, A. ; Fraquelli, M. / Iron-related indexes in chronic alcoholics. Effect of alcohol withdrawal. In: Italian Journal of Gastroenterology and Hepatology. 1998 ; Vol. 30, No. 5. pp. 534-538.
@article{38ba007eab9c45a6ad48e454fb3a26e0,
title = "Iron-related indexes in chronic alcoholics. Effect of alcohol withdrawal",
abstract = "Background. Increased serum transferrin saturation and ferritin levels have been reported in chronic alcoholics. Aim. To evaluate modifications in serum iron-related indexes in chronic alcohol abusers with and without cirrhosis, at enrolment and after complete alcohol withdrawal. Patients. Fifty-one consecutive chronic alcohol abusers, 33 without and 18 with cirrhosis. Methods. Liver function tests were performed and transferrin saturation percent and serum ferritin levels measured at time 0 and after 7 and 14 days of complete alcohol withdrawal. Results. Duration of alcohol abuse was significantly longer in patients with cirrhosis than in those without (24 ± 13 SD vs 18 ± 13 SD years, p <0.01). A concomitant increase in transferrin saturation percent and serum ferritin was found in 60{\%} of the cirrhotics and 45{\%} of the non cirrhotic group. During the observation period transferrin saturation percent and serum ferritin fell significantly in both groups (from 59 ± 33 SD to 36 ± 22{\%} SD, p <0.05, and from 900 ± 933 SD to 469 ± 457 SD ng/ml, p <0.01, in cirrhotics, and from 46 ± 30 SD to 27 ± 12{\%} SD, p <0.01, and from 702 ± 602 SD to 340 ± 290 SD ng/ml, p <0.01, in non cirrhotics). Conclusions. Iron-related indexes increase with chronic alcohol abuse and return to normal rapidly after complete alcohol withdrawal. In chronic alcoholics the timing of determinations of iron-related indexes is crucial, and screening for possible concomitant genetic haemochromatosis must be postponed.",
keywords = "Alcohol abuse, Alcohol withdrawal, Cirrhosis, Ferritin, Haemochromatosis, Hepatitis B virus, Hepatitis C virus, Transferrin",
author = "D. Conte and M. Corsetti and A. Colli and Bardella, {M. T.} and M. Cocciolo and A. Maestroni and M. Fraquelli",
year = "1998",
language = "English",
volume = "30",
pages = "534--538",
journal = "Digestive and Liver Disease",
issn = "1590-8658",
publisher = "Elsevier B.V.",
number = "5",

}

TY - JOUR

T1 - Iron-related indexes in chronic alcoholics. Effect of alcohol withdrawal

AU - Conte, D.

AU - Corsetti, M.

AU - Colli, A.

AU - Bardella, M. T.

AU - Cocciolo, M.

AU - Maestroni, A.

AU - Fraquelli, M.

PY - 1998

Y1 - 1998

N2 - Background. Increased serum transferrin saturation and ferritin levels have been reported in chronic alcoholics. Aim. To evaluate modifications in serum iron-related indexes in chronic alcohol abusers with and without cirrhosis, at enrolment and after complete alcohol withdrawal. Patients. Fifty-one consecutive chronic alcohol abusers, 33 without and 18 with cirrhosis. Methods. Liver function tests were performed and transferrin saturation percent and serum ferritin levels measured at time 0 and after 7 and 14 days of complete alcohol withdrawal. Results. Duration of alcohol abuse was significantly longer in patients with cirrhosis than in those without (24 ± 13 SD vs 18 ± 13 SD years, p <0.01). A concomitant increase in transferrin saturation percent and serum ferritin was found in 60% of the cirrhotics and 45% of the non cirrhotic group. During the observation period transferrin saturation percent and serum ferritin fell significantly in both groups (from 59 ± 33 SD to 36 ± 22% SD, p <0.05, and from 900 ± 933 SD to 469 ± 457 SD ng/ml, p <0.01, in cirrhotics, and from 46 ± 30 SD to 27 ± 12% SD, p <0.01, and from 702 ± 602 SD to 340 ± 290 SD ng/ml, p <0.01, in non cirrhotics). Conclusions. Iron-related indexes increase with chronic alcohol abuse and return to normal rapidly after complete alcohol withdrawal. In chronic alcoholics the timing of determinations of iron-related indexes is crucial, and screening for possible concomitant genetic haemochromatosis must be postponed.

AB - Background. Increased serum transferrin saturation and ferritin levels have been reported in chronic alcoholics. Aim. To evaluate modifications in serum iron-related indexes in chronic alcohol abusers with and without cirrhosis, at enrolment and after complete alcohol withdrawal. Patients. Fifty-one consecutive chronic alcohol abusers, 33 without and 18 with cirrhosis. Methods. Liver function tests were performed and transferrin saturation percent and serum ferritin levels measured at time 0 and after 7 and 14 days of complete alcohol withdrawal. Results. Duration of alcohol abuse was significantly longer in patients with cirrhosis than in those without (24 ± 13 SD vs 18 ± 13 SD years, p <0.01). A concomitant increase in transferrin saturation percent and serum ferritin was found in 60% of the cirrhotics and 45% of the non cirrhotic group. During the observation period transferrin saturation percent and serum ferritin fell significantly in both groups (from 59 ± 33 SD to 36 ± 22% SD, p <0.05, and from 900 ± 933 SD to 469 ± 457 SD ng/ml, p <0.01, in cirrhotics, and from 46 ± 30 SD to 27 ± 12% SD, p <0.01, and from 702 ± 602 SD to 340 ± 290 SD ng/ml, p <0.01, in non cirrhotics). Conclusions. Iron-related indexes increase with chronic alcohol abuse and return to normal rapidly after complete alcohol withdrawal. In chronic alcoholics the timing of determinations of iron-related indexes is crucial, and screening for possible concomitant genetic haemochromatosis must be postponed.

KW - Alcohol abuse

KW - Alcohol withdrawal

KW - Cirrhosis

KW - Ferritin

KW - Haemochromatosis

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - Transferrin

UR - http://www.scopus.com/inward/record.url?scp=0031771181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031771181&partnerID=8YFLogxK

M3 - Article

C2 - 9836113

AN - SCOPUS:0031771181

VL - 30

SP - 534

EP - 538

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 5

ER -