Iron Serum Markers Profile in Frontotemporal Lobar Degeneration

Anastasia De Luca, Silvia Fostinelli, Clarissa Ferrari, Giuliano Binetti, Luisa Benussi, Barbara Borroni, Luisa Rossi, Mauro Rongioletti, Roberta Ghidoni, Rosanna Squitti

Research output: Contribution to journalArticlepeer-review

Abstract

Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative syndrome. Defects of copper (Cu) and iron (Fe) homeostasis are involved in the development of several neurodegenerative diseases and their homeostasis is interconnected by the Cu-protein ceruloplasmin (Cp), responsible for Fe oxidative state. In this study we assessed Fe, transferrin (Trf), ferritin, Cp specific activity (eCp/iCp), Cp/Trf ratio, and Trf saturation in 60 FTLD patients and 43 healthy controls, and discussed the results in relation to Cu homeostasis. The significant decrease of the eCp/iCp in the FTLD patients supports the involvement of Fe imbalance in the onset and progression of FTLD.

Original languageEnglish
Pages (from-to)1373-1380
Number of pages8
JournalJournal of Alzheimer's Disease
Volume78
Issue number4
DOIs
Publication statusPublished - 2020

Keywords

  • Ceruloplasmin
  • copper
  • frontotemporal dementia
  • iron
  • serum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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